重庆医学2011，Vol.40Issue(36)：3701-3702,2.DOI:10.3969/j.issn.1671-8348.2011.36.027
慢性阻塞性肺疾病急性加重期患者血浆SP-D水平测定及临床意义
Detection and its clinical significance of serum SP-D level in patients with acute exacerbation of chronic obstructive pulmonary disease
吴友茹 1陈明勇 1李惠1
作者信息
- 1. 四川省绵阳市中心医院呼吸内科,621000
- 折叠
摘要
Abstract
Objective To detect the content of serum pulmonary surfatcant-associated protein D(SP-D) in patients with chronic obstructive pulmonary disease(COPD) during acute exacerbation and in stable phase and discuss its clinical significance. Methods 69 patients with acute exacerbation of COPD(AECOPD) which achieved remission during and after hospital treatment were selec ted. Double-antibody sandwich enzyme linked immunosorbent assay was employed to measure the concentration of serum SP-D,and the complete blood count test was performed simultaneously. 42 cases of healthy people accepted physical examine served as control. Results Average concentration of serum SP-D in patients with AECOPD during acute exacerbation and in stable phase were (183 + 86) ,( 126 + 72) ng/mL, respectively, while that in control group[( 96 ± 47) ng/mL]. There were statistically significant differences between patients with AECOPD and patients in stable phase or in control group(P<0. 01). The positive rate of serum SP-DD in patients with AECOPD were 85. 50% which demonstrated statistical difference when compared with those of WBC and neutrophils(P<0. 01). Conclusion Serum SP-D may be a potential biological indicator for AECOPD diagnosis.关键词
肺疾病,慢性阻塞性/肺表面活性物质相关蛋白质D/血浆/急性加重期Key words
pulmonary disease,chronic obstructive/pulmonary surfactant-associated protein D/plasma/acute exacerbation引用本文复制引用
吴友茹,陈明勇,李惠..慢性阻塞性肺疾病急性加重期患者血浆SP-D水平测定及临床意义[J].重庆医学,2011,40(36):3701-3702,2.
