老年医学与保健2011，Vol.17Issue(6)：357-359,3.DOI:10.3969/j.issn.1008-8296.2011-06-13
糖尿病合并急性冠脉综合征患者血清esRAGE与CRP的相关研究
Association of endogenous secretory receptor for advanced glycation end products (esRAGE) and C reactive protein (CRP) with acute coronary syndrome (ACS) in type 2 diabetes mellitus
摘要
Abstract
Objective To evaluate the association of endogenous secretory receptor for advanced glycation end products (esRAGE) and C reactive protein (CRP) with acute coronary syndrome (ACS) in type 2 diabetes mellitus. Methods Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum esRAGE of all the patients which were divided into three groups, other clinical index was also tested. Results Serum esRAGE level was significantly lower in T2DM with ACS than in T2DM with coronary artery disease (CAD) and without CAD (P<0.01), and was also significantly lower in T2DM with CAD than in the T2DM without CAD (P<0.01). Serum CRP level was significantly higher in T2DM with ACS than in T2DM with coronary artery disease (CAD) and without CAD (P<0.01), and was also significantly higher in T2DM with CAD than in the T2DM without CAD (P<0.01). Pearson correlation analysis showed the level of serum esRAGE was inversely correlated with the level of CRP. Conclusions esRAGE is strongly associated with ACS in T2DM, and probably is a potential protective factor for diabetes with vascular complication and is closely related to inflammation.关键词
内源性分泌型糖基化代谢终末产物受体/C反应蛋白/2型糖尿病/急性冠脉综合征Key words
Endogenous secretory receptor for advanced glycation end products/ C reactive protein/ Type 2 diabetes mellitus/ Acute coronary syndrome分类
医药卫生引用本文复制引用
施珍,王瑞良,陈书艳..糖尿病合并急性冠脉综合征患者血清esRAGE与CRP的相关研究[J].老年医学与保健,2011,17(6):357-359,3.基金项目
上海市教委优秀青年教师培养支助基金(JDY08082) （JDY08082）
