重庆医学2011，Vol.40Issue(36)：3708-3710,3.DOI:10.3969/j.issn.1671-8348.2011.36.030
姜黄素对神经病理性疼痛大鼠脊髓背角和背根神经节GR和NMDAR-NR1表达的影响
Effects of curcumin on expression of GR and NMDAR-NR1 in posterior horn and dorsal root ganglia of rats with neuropathic pain
余相地 1柯齐斌 1汤和清 1陈春 1陈明全 1侯俊 1方为1
作者信息
- 1. 三峡大学第一临床医学院/湖北省宜昌市中心人民医院麻醉科,湖北宜昌,443003
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摘要
Abstract
Objective To explore the effects of curcumin on expression of glucocorticoid receptor(GR) and NMDAR-NR1 in posterior horn and dorsal root ganglia of rats with neuropathic pain. Methods 72 male SD rats, weighing 220-250 g, were randomly divided into four groups: sham operation group(sham group) , chronic constriction injury (CO) group, CCI+solvent group(SC group) and CCI+curcumin 100 mg/kg group(Cur100 group). After sciatic nerve ligation,rats in SC group and Cur100 group were subjected to intraperitoneal injection of solvent or curcumin 100 mg · Kg-1 · D-1 , respectively, until 14 days after operation. Mechanical withdrawal threshold(MWT) and thermal withdrawal latency(TWL) of rats were measured 2 days before operation and 1, 3,5,7,10 and 14 days after operation. L4 , L5 posterior horn and dorsal root ganglia of rats on the operative side were chosen 3,7 and 14 days after operation,and immunohistochemistry was used to detect the expression of GR and NMDAR-Nri in posterior horn and dorsal root ganglia of rats. Results Compared with the sham group,TWL and MWT decreased markedly(P<0. 01) , while expression of GR and NMDAR-Nri in posterior horn and dorsal root ganglia on the operative side increased significantly(P<0. 01) after operation in CCI group. Compared with CCI group, TWL and MWT increased markedly(P<0. 05) , while expression of GR and NMDAR-Nri in posterior horn and dorsal root ganglia decreased significantly(P<0. 05) in Cur100 group. Conclusion Curcumin may reduce neuropathic pain of rats with CCI via inhibition the expression of GR and NMDAR-Nri in posterior horn and dorsal root ganglia.关键词
疼痛/姜黄素/受体,糖皮质激素/D-天氡氨酸/大鼠Key words
pain/ curcumin/receptors, glucocorticoid/D-aspartic acid/ rats引用本文复制引用
余相地,柯齐斌,汤和清,陈春,陈明全,侯俊,方为..姜黄素对神经病理性疼痛大鼠脊髓背角和背根神经节GR和NMDAR-NR1表达的影响[J].重庆医学,2011,40(36):3708-3710,3.
