医药导报2012，Vol.31Issue(1)：40-42,3.DOI:10.3870/yydb.2012.01.015
右美托咪定用于老年患者低位硬膜外麻醉22例
Dexmedetomidine for Sedation During Low Epidural Anesthesia in 22 Elderly Patients
廖明锋 1迟晓慧 1邓玉春 1张雪 1杨辉 1罗爱林1
作者信息
- 1. 华中科技大学同济医学院附属同济医院麻醉学教研室,武汉430030
- 折叠
摘要
Abstract
Objective To assess the security and optimal dosage of using dexmedetomidine for sedation during low epidural anesthesia in the elderly patients. Methods A total of 48 elderly patients undergoing transurethral resection prostate were randomly divided into two groups: dexmedetomidine group and control one, 24 patients in each group. All patients received low epidural anesthesia with 1.5% lidocaine. Infusion of dexmedetomidine started 10 minutes before operation at a loading dose of 0.5μg · kg-1 in the test group, with a reduction of 0. 1 μg · kg-1 · h-1 once to a maintenance dose of 0. 2 μg · kg-1 · h-1 for keeping the Richmond Agitation-Sedation Scale ( RASS ) to at level -2. Patients in the control received no sedative treatment. The sedation assessment, vital signs and post-operation complication were observed. Results Twenty-two patients in the dexmedetomidine group completed evaluation, and they were in a stable sedation state. Moreover, lower heart rate, more satisfaction and less shivering were observed ( P<0. 05 ). The optimal dose of dexmedetomidine for sedation during low epiduralanesthesia in elderly patients was proposed at 0. 2-0. 3 μg · kg-1 · h-1. Conclusion Loading 0. 5 μg · kg-1 dexmedetomidine followed by maintaining infusion at 0. 2-0. 3 μg · kg-1· h-1 could provide a good and stable sedative effect during low epidural anesthesia in elderly patients.关键词
右美托咪定/利多卡因/镇静/硬膜外麻醉Key words
Dexmedetomidine/Lidocaine/Sedation/Epidural anesthesia分类
医药卫生引用本文复制引用
廖明锋,迟晓慧,邓玉春,张雪,杨辉,罗爱林..右美托咪定用于老年患者低位硬膜外麻醉22例[J].医药导报,2012,31(1):40-42,3.
