中国组织工程研究与临床康复2011，Vol.15Issue(49)：9235-9238,4.DOI:10.3969/j.issn.1673-8225.2011.49.027
骨髓间充质干细胞移植治疗mdx鼠:3个月疗效
Three-month therapeutic effect of bone marrow mesenchymal stem cells transplantation on the treatment of X-linked muscular distrophy mice
摘要
Abstract
BACKGROUND: Stem cells trans plantation fo. Treatment of x-limked muscular dystrophy (mdx) is the reseach hotspct. To compare with hematopoietic stem cells transplantation, mesenchymal stem cells transplantation has less risk. OBJECTIVE: To study the effect of bone marrow mesenchymal stem cells t.ansplantation on the treatment of Duchenne muscular distrophy(DMD) mice.METHODS: Sixteen 4-week.old mdx mice were randomly divided Mo two groups: control group and transplanted group, eight mice in each group. C57BL/8 mice bone marrow mesenchymal stem cells or normal saline were injected intravenously and intramuscularly into the mice in transplanted group, respectively.RESULT SAND CONCLUSION: Three months after transplantation. The serum.eatinekinase in transplanted group mis decreased obviously, and the expression of dystrophin protein could be seen on the skeletal muscle membrane. There was on expression of dystrophin protein in control group. There were no obvious changes of motor function in two groups. Bone marrow mesenchymal stem cells transplantation had some therapeutic effect on the treatment of mdx mice, it mightreduce the damage of muscle cell membrane and delay the progression of the disease.关键词
骨髓/间充质干细胞/mdx鼠/肌营养不良/肌酸激酶/dystrophin蛋白分类
医药卫生引用本文复制引用
许忆峰,杨晓凤,王红梅,张轶斌,吕乃武,周金旭..骨髓间充质干细胞移植治疗mdx鼠:3个月疗效[J].中国组织工程研究与临床康复,2011,15(49):9235-9238,4.基金项目
辽宁省重大课题攻关项目(2008225009). （2008225009）
