中国药理学通报2012，Vol.28Issue(1)：16-19,4.DOI:10.3969/j.issn.1001-1978.2012.005.
CYP3A4高表达细胞模型及其应用于药物代谢研究进展
Advances in CYP3A4 over-expressed cell models and their application to drug metabolism research
摘要
Abstract
Cytochrome P450 3A4( CYP3A4 ),one of cytochrome P450 enzymes family , is involved in metabolism and interaction of various compounds, and a key target for drug screening and metabolism research. This article tries to review the development of CYP3A4 over-expressed cellular models, and their applicationin drug metabolism and drug-drug interaction in chronological sequence. The aim is to introduce the valuable models to research on new drugs.关键词
CYP3A4/高表达/细胞模型/药物代谢/药物相互作用/药物筛选Key words
CYP3A4/ over expression/ cell model/ drug metabolism/ drug-drug interaction/ drug screening分类
医药卫生引用本文复制引用
李蒙,朱传江..CYP3A4高表达细胞模型及其应用于药物代谢研究进展[J].中国药理学通报,2012,28(1):16-19,4.基金项目
国家自然科学基金资助项目(No 30873117) （No 30873117）
科技部"重大新药创制"科技重大专项基金资助(No 2009ZX09501-018,2009ZX09301-003-51) （No 2009ZX09501-018,2009ZX09301-003-51）
