CYP3A4高表达细胞模型及其应用于药物代谢研究进展OA北大核心CSCDCSTPCD
Advances in CYP3A4 over-expressed cell models and their application to drug metabolism research
细胞色素P450酶3A4(cytochrome P450 3A4,CYP3A4)属于细胞色素P450酶家族,参与多种化合物代谢及相互作用,是药物(尤其是口服药物)筛选和代谢研究的重要对象.该文按年代顺序对国外文献中CYP3A4高表达细胞模型的建立及在药物代谢中的应用进行综述,旨在将这一有价值的模型引入到新药研究中.
Cytochrome P450 3A4( CYP3A4 ),one of cytochrome P450 enzymes family , is involved in metabolism and interaction of various compounds, and a key target for drug screening and metabolism research. This article tries to review the development of CYP3A4 over-expressed cellular models, and their applicationin drug metabolism and drug-drug interaction in chronological sequence. The aim is to introduce the valuable models to research on new drugs.
李蒙;朱传江
天然药物活性物质与功能国家重点实验室,中国医学科学院北京协和医学院药物研究所,北京,100050天然药物活性物质与功能国家重点实验室,中国医学科学院北京协和医学院药物研究所,北京,100050
医药卫生
CYP3A4高表达细胞模型药物代谢药物相互作用药物筛选
CYP3A4 over expression cell model drug metabolism drug-drug interaction drug screening
《中国药理学通报》 2012 (1)
P-糖蛋白和P4503A对黄皮酰胺对映体在靶组织中生物利用度的影响
16-19,4
国家自然科学基金资助项目(No 30873117)科技部"重大新药创制"科技重大专项基金资助(No 2009ZX09501-018,2009ZX09301-003-51)
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