中国组织工程研究与临床康复2011，Vol.15Issue(52)：9696-9700,5.DOI:10.3969/j.issn.1673-8225.2011.52.002
维药买朱尼对骨关节炎大鼠模型关节软骨中基质金属蛋白酶1和基质金属蛋白酶抑制剂1的影响
Effect of Uygur medicine Maizhuni on the expression of matrix metalloproteinase 1 and tissue inhibitor of matrix metalloproteinase 1 in the articular cartilage of rat osteoarthritis models
摘要
Abstract
BACKGROUND: Articular cartilage damage in osteoarthritis patients is related to the imbalance between matrixmetalloproteinase 1 and tissue inhibitors of matrix metalloproteinase.OBJECTIVE: To investigate the expression of matrix metalloproteinase 1 and tissue inhibitor of matrix metalloproteinase 1 inarticular cartilage and the intervention effects of Uygur medicine Maizhuni.METHODS: Knee osteoarthritis model was constructed using modified Hulth method. A total of 20 healthy SD rats were randomlydivided into Maizhuni group and model group. Rats were treated with Uygur medicine Maizhuni or saline by gavage in the 2ndweek after model construction for 4 weeks.RESULTS AND CONCLUSION: Compared with model group, the degree of rat knee joint cartilage degeneration in Maizhunigroup was alleviated. The cartilage general score and Mankin score in Maizhuni group was lower than that in the model group (P< 0.05). The expression of matrix metalloproteinase 1 in knee joint chondrocytes of Maizhuni group decreased than that of thecontrol group (P < 0.05); the expression of tissue inhibitor of matrix metalloproteinase 1 in Maizhuni group increased than that inthe model group (P < 0.05). These findings indicate that Uyghur medicine Maizhuni may protect articular cartilage bydown-regulating the expression of matrix metalloproteinase 1 and up-regulating the expression of tissue inhibitor of matrixmetalloproteinase 1.关键词
基质金属蛋白酶/骨关节炎/关节软骨/基质金属蛋白酶抑制剂/买朱尼分类
医药卫生引用本文复制引用
张耀武,方锐,刘振峰,艾力江·阿斯拉,孟庆才..维药买朱尼对骨关节炎大鼠模型关节软骨中基质金属蛋白酶1和基质金属蛋白酶抑制剂1的影响[J].中国组织工程研究与临床康复,2011,15(52):9696-9700,5.基金项目
新疆维吾尔自治区自治区科技支撑计划项目(200933126). （200933126）
