中国组织工程研究与临床康复2011，Vol.15Issue(52)：9764-9766,3.DOI:10.3969/j.issn.1673-8225.2011.52.017
髋关节置换后药物预防深静脉血栓的分组对照
Prevention and medical treatment of deep vein thrombosis after hip replacement: A controlled trial
张志 1范玉伟 1杨艺民 1王建新1
作者信息
- 1. 固原市人民医院骨科,宁夏回族自治区固原市,756000
- 折叠
摘要
Abstract
BACKGROUND: Deep vein thrombosis (DVT) after hip replacement operation is one of risk complications. Drug therapy is aneffective way to prevent thrombosis. To achieve the best preventive effect, standardized medication program is used in clinical.OBJECTIVE: To summarize the prevention and treatment experience of DVT in patients after hip replacement operation.METHODS: Totally 110 patients who received hip replacement from Department of Orthopedics, Guyuan City People's Hospitalbetween January 2010 and May 2011 were analyzed retrospectively. Clinical data of the patients who received low molecularweight heparin, Fondaparinux sodium, Rivaroxaban and warfarin for prevention of DVT were selected according to therequirement of China Orthopedic Surgery Venous Thromboembolism Prevention Guideline (2009 edition). Above-mentionedclinical results were compared with the clinical data from 123 patients who were also received hip replacement but were treatedwith drug irregularly to prevent DVT postoperatively between January 2007 and December 2009.RESULTS AND CONCLUSION: All the patients had no obviously uncomfortable symptoms after anticoagulant injection. Fewpatients with DVT in the both groups were found. D-dimer detection of 45 and 29 cases in the irregular group and the regular groupwere positive respectively. DVT of the two groups occurred at 4 weeks after hip replacement. Incidence of thrombosis wasdecreasing with the medication time. Patients with thrombosis in the regular group were obviously lower than those in the irregulargroup at 12 weeks after hip replacement (P < 0.05). It is indicated that to regularly use low molecular weight heparin, Fondaparinuxsodium, Rivaroxaban and warfarin can efficiently prevent the occurrence of DVT after hip replacement.关键词
髋关节置换/深静脉血栓形成/药物/预防/骨科大手术分类
基础医学引用本文复制引用
张志,范玉伟,杨艺民,王建新..髋关节置换后药物预防深静脉血栓的分组对照[J].中国组织工程研究与临床康复,2011,15(52):9764-9766,3.
