中国组织工程研究与临床康复2011，Vol.15Issue(50)：9449-9452,4.DOI:10.3969/j.issn.1673-8225.2011.50.034
南极大磷虾胰蛋白酶可促进创面的愈合
Antarctic krill trypsin promotes wound healing
摘要
Abstract
BACKGROUND: It is confirmed that trypsin has better effects on debridement and wound healing.OBJECT FVE: To explore the effects of the Antarctic krill trypsin on wound healing.METHODS: Back trauma model in Hew Zealand white rabbits was established by defecting full-thid<ness skin. There were fourwounds in each rabbit, treated with crude trypsin. Pure trypsin extracted from Antarctickrill, papin and saline, respectively. Thewounds were treated twice daily until healed.RESULT SAND CONCLUSION: According to the healing area at the 5h. 1Oh and 15hdays after tre atme nt. Crude trypsin andpure trypsin extracted from Antarctic kr ill had a better effect on wound healing. Crude trypsin was better than pure trypsin. The005). The content determination results of skin hydroxyproline showed that crude trypsin significant^ improved the synthesE andthe treatment. These results demonstrate that Antarctic k rill trypsin can promote wound healing in New Zealand white rabbit, and the crude typsin has the best effect.关键词
南极大磷虾/胰蛋白酶/创伤愈合/新西兰大白兔/羟脯氨酸分类
基础医学引用本文复制引用
张鹏,姜国良,王军仁..南极大磷虾胰蛋白酶可促进创面的愈合[J].中国组织工程研究与临床康复,2011,15(50):9449-9452,4.基金项目
山东省自然科学基金(ZR2010DQ012)资助项目,项目名称:南极大磷虾(Euphausia superba)胰蛋白酶适冷性结构特征及酶学性质研究. （ZR2010DQ012）
