中国组织工程研究与临床康复2011，Vol.15Issue(50)：9311-9313,3.DOI:10.3969/j.issn.1673-8225.2011.50.001
木瓜蛋白酶诱导膝关节骨关节炎模型兔滑膜病理变化与药物注射时间的关系
Relationship between synovium pathological change and injection timing in rabbits with papain-induced knee osteoarthritis
孙鲁宁 1赵燕华 2黄桂成 1夏建龙1
作者信息
- 1. 南京中医药大学,江苏省南京市210029
- 2. 江苏省中医院骨科,江苏省南京市,210029
- 折叠
摘要
Abstract
BACKGROUND: A stable degenerative knee osteroarthritis model in rabbits can be established by the induction of papain. OBJECT IVE: To explore the relationship between the pathological change of synovium and injection timing in rabbits with kneeMETHODS: Papain solution was injected into the right knee joint cavity of 15 Hew Zealand white rabbits on the 1sl.4hand7h2rd , 4h and Bh weeks after first injection. Five rabbits were examined at each time point.RESULT SAND CONCLUSION: The synovium inflammatory reaction of rabbit knee joint was the most serious at the 2rd weekafter the first injection of papain, characterized by the most obvious proliferation of synovia I cell, obvious proliferation of vas:cuarreaction relieved gradualy in the 4h and 6h weeks. These results il lustrate th at th e syn oviu m inf lammato ry reaction of knee joint in rabbits reach its maximum effect in the 2rd week after the fifst injection of papain.关键词
木瓜蛋白酶/膝关节/骨关节炎/滑膜炎/动物模型/组织构建分类
医药卫生引用本文复制引用
孙鲁宁,赵燕华,黄桂成,夏建龙..木瓜蛋白酶诱导膝关节骨关节炎模型兔滑膜病理变化与药物注射时间的关系[J].中国组织工程研究与临床康复,2011,15(50):9311-9313,3.
