医药导报2012，Vol.31Issue(1)：8-10,3.DOI:10.3870/yydb.2012.01.003
杏苏止咳糖浆的药效学研究
Preliminary Pharmacodynamic Study of Xingsu Zhike Syrup
摘要
Abstract
Objective To study the expectorant, anti-tussive, anti-asthmatic and anti-inflammatory effects of xingsu zhike syrup. Methods Mice were divided into five groups at random, including normal control, kechuanning group (3.0 mL · kg-1 ), and three groups received with low dose, middle dose and high dose of xingsu zhike syrup( 1. 5,3. 0, 6. 0 mL · kg-1 ), respectively. The rat model with cough by ammonia, mouse model for testing phenol red excretion, mouse model of histamine-acetylcholine induced asthma and that with celiac capillary permeation by acetic acid were created to explore effect of xingsu zhike syrup. Results Cough frequency within 2 minutes of the medium, low dose groups of xingsu zhike syrup, and blank control were( 40.50±9. 53 ),( 36.73±10. 40 ),( 36. 54±7. 24 ),( 28. 07±4. 83 ),( 44. 72±6. 97 )times, respectively. The latent period of cough induced was( 24. 56 ± 10. 83 ),(26. 22±9. 17 ), ( 26. 92±8. 69 ), ( 28. 62± 11. 58 ), ( 18. 49±5. 56) s,respectively. The latent period of incubation induced was( 64. 8±17. 9 ),( 68.4±18. 3 ),(75.8±20. 7 ),( 73. 6±17. 8 ),( 49. 8± 15. 4 ) s , respectiYely. The absorbency reflecting phenol red discharge was( 0. 096±0. 025 ),( 0. 103±0. 021 ),( 0. 110±0. 035 ), (0.110±0.032),(0. 083 ±0.022), respectively, that for capillary permeability was( 0. 107 ±0. 034 ),( 0. 103 ±0.027 ), (0.090±0.024),( 0. 099±0. 031 ), ( 0. 121 ±0. 037 ), respectiYely. Conclusion Xingsu zhike syrup has significant expectorant, anti-tussive, anti-asthmatic and anti-inflammatory effects.关键词
杏苏止咳糖浆/镇咳/祛痰/平喘/抗炎Key words
Xingsu zhike syrup/Anti-tussive/Expectorant/Anti-asthmatic/Anti-inflammatory分类
医药卫生引用本文复制引用
张士勇,程军,彭代银,高家荣..杏苏止咳糖浆的药效学研究[J].医药导报,2012,31(1):8-10,3.基金项目
蚌埠市科技计划项目(蚌科[2011]33) （蚌科[2011]33）
