浙江医学2011，Vol.33Issue(12)：1735-1737,3.
氢质子磁共振波谱分析对脑卒中后血管性痴呆患者的诊断价值
1H-magnetic resonance spectroscopy in diagnosis of vascular dementia after stroke
摘要
Abstract
To investigate the diagnostic value of 1H-magnetic resonance spectroscopy (1H-MRS) for vas-cular dementia! VD) in stroke patients.MethodsEighteen stroke patients with VD, 13 stroke patients without VD and 14 healthysubjects matched for age were enrolled in the study. 1H-MRS examinations of bilateral hippocampus were conducted in all patients; the N-acetylaspartate( NAA),choline(Cho)and creatine(Cr)were measured and the ratios of NAA/Cr and Cho/Cr were compared among groups.The patients with VD had a significantly lower NAA/Cr ratio in bilateral temporal hippocam-pus regions than normal controls and the stroke patients without VD (P<0.01 ,P<0.05),and had a higher Cho/Cr ratio than normal controls (P<0.05). The Cho/Cr ratio of left hippocampus in patients with VD was higher than that in patients without VD( P< 0.05),but there was no significantly difference in right hippocampus between two groups (P >0.05). There were no significant differences in NAA/Cr ratio and Cho/Cr ratio between patients without VD and normal controls. Relative-regression analysis found that MMSE scores were positively correlated with NAA/Cr and negatively correlated with Cho/Cr in bilateral hippocampus regions in patients with VD.ConclusionThe metabolic status of bilateral hippocampus regions examined by 1H-MRS might be of valuein early detection of vascular dementia in stroke patients.关键词
脑卒中/血管性痴呆/磁共振波谱/海马Key words
Stroke/ Vascular dementia/ Magnetic resonance spectroscopy / Hippocampus引用本文复制引用
李瑾,乐先杰,何迎春..氢质子磁共振波谱分析对脑卒中后血管性痴呆患者的诊断价值[J].浙江医学,2011,33(12):1735-1737,3.基金项目
浙江省医药卫生科学研究基金项目(2006A102) （2006A102）
