疑难病杂志2012，Vol.11Issue(1)：23-25,3.DOI:10.3969 / j.issn.1671-6450.2012.01.008
脑梗死患者可干预危险因素与单核细胞趋化蛋白-1基因2518G/A多态性的关系研究
Correlation between interfered risk factors of cerebral infarction and polymorphism of monocyte chemoattractant protein-1 gene 2518G/A
杨月仙 1马虹 1李建兵 1张茂林 2张树雄 1张改梅 1王永霞 1杨丽荣1
作者信息
- 1. 014040,包头市,蒙医中医医院神经内科
- 2. 014030,包头,医学院第一附属医院神经内科
- 折叠
摘要
Abstract
Objective To explore the correlation between interfered risk factors of cerebral infarction and monocyte chemoattractant protein-l( MCP-1 )gene 2518G/A polymorphism. Methods With technique of polymerase chain reaction-restriction fragment length polymorphism( PCR-RFLP ), MCP-1 genotype and gene frequency distribution were detected in 148 cases of cerebral infarction and 130 normal person. Retrospectively reviewed the distribution of diabetes, hypertension, hyper-lipemia and smoking between the two groups and performed the statistical analysis. Results ( 1 ) There was no significant differences of MCP-1 gene 2518G/A genotypes and allele frequency distribution in people whether or not with hypertension, hyperlipemia,diabetes mellitus smoking( P >0. 05 ). ( 2 )There was no significant difference of the infarction ratio whether people with diabetes mellitus, hypertension, hyperlipemia, smoking or not( P >0. 05 ). Conclusion These result suggested that there was no correlation between MCP-1 gene 2518G/A gene polymorphisms and diabetes mellitus, hypertension, hyperlipemia, and smoking. There were no synergism between MCP-1 gene 2518G mutation and hyperlipemia, diabetes mellitus, hypertension, smoking in cerebral infarction patients.关键词
脑梗死/危险因素/单核细胞趋化蛋白-1/基因多态性Key words
Cerebral infarction/Risk factor/MCP-1/Gene polymorphism引用本文复制引用
杨月仙,马虹,李建兵,张茂林,张树雄,张改梅,王永霞,杨丽荣..脑梗死患者可干预危险因素与单核细胞趋化蛋白-1基因2518G/A多态性的关系研究[J].疑难病杂志,2012,11(1):23-25,3.
