浙江医学2011，Vol.33Issue(12)：1766-1768,1807,4.
胃癌患者S100A4蛋白高水平表达与淋巴结转移及胃癌不良预后的相关性
High-level expression of S100A4 is correlated with lymph node metastasis and poor prognosis in patients with gastric cancer
倪海滨 1叶再元 1赵仲生 2王元宇1
作者信息
- 1. 310014,杭州,浙江省人民医院普外科
- 2. 310014,杭州,浙江省人民医院普病理科
- 折叠
摘要
Abstract
To investigate the expression of S100A4 in gastric cancer and its association with tumor develop-ment, progression and metastasis.MethodsImmunohistochemistry was employed to analyze S100A4 expression in tissuespecimens of 436 cases with gastric cancer.ResultsS100A4 protein was detected in 261 of 436 cases of human gastric cancer,and highly expressed in 187 cases. Positive expression of S100A4 was correlated with age, tumor location, size, depth of invasion, lymph node and distant metastases, Lauren classification, regional lymph node stage, and TNM stage; but not correlated with sex, differentiation, or histological classification. In stage I, II, and III tumors, the 5-year survival rate in patients with high expression of S100A4 was significantly lower than that in patients with low expression. In stage IV tumors, expression of S100A4 was not correlate with the 5-year survival rate. Multivariate analysis suggested that depth of invasion, lymph node and distant metastases, TNM stage and upregulation of S100A4 were independent prognostic indicators for the disease.ConclusionExpression of S100A4 in gastric cancer is significantly associated with lymph node and distant metastases, and poor prognosis. S100A4 may be a useful marker to predict development, progression, and metastasis of gastric cancer.关键词
胃癌/S100A4/淋巴结转移/预后Key words
Gastric cancer/ S100A4 / Lymph node metastases Prognosis引用本文复制引用
倪海滨,叶再元,赵仲生,王元宇..胃癌患者S100A4蛋白高水平表达与淋巴结转移及胃癌不良预后的相关性[J].浙江医学,2011,33(12):1766-1768,1807,4.
