浙江医学2011，Vol.33Issue(12)：1777-1780,4.
HIF-1α和PTEN蛋白在异位子宫内膜中的表达及临床意义
Expression of HIF-1α and PTEN in endometriosis and its clinical significance
王步军 1郑飞云 2杨孝军 2张乾2
作者信息
- 1. 325400,平阳县人民医院妇科
- 2. 温州医学院附属第一医院妇科
- 折叠
摘要
Abstract
To investigate the expression of HIF-1 a and PTEN in endometriosis (Ems) and its clinical signifi-cance.MethodsThe expression of HIF-1a and PTEN were detected by immunohistochemical technique in 58 specimens ofectopic endometrium and 25 specimens of eutopic endometrium from 38 Ems patients, and 20 specimens of normal endometri-um. The correlation of HIF-1a and PTEN expression with treatment, recurrence and pregnancy of patients was analyzed. The positive rate of HIF-1a in ectopic endometrium, eutopic endometrium of Ems patients was higher and PTEN was lower than those in normal endometrium (both P<0.05). HIF-1a was significantly higher in secretary phase than that in proliferative phase both in ectopic and eutopic endometrium of Ems patients (P<0.05),but not in normal endometrium. There was no difference in PTEN expression between secretary phase and proliferative phase of endometrium. The expression of HIF-1 a and PTEN was not correlated with age, dysmenorrhea, cyst diameter, pregnancy of Ems patients, but correlated with clinical staging and recurrence after operation (P<0.05). There was negative correlation between HIF-1a and PTEN expression in endometrium (P<0.05). The results suggest that the interaction of HIF-1 a and PTEN may be involved in the ectopic implantation and development of endometriosis cells in Ems patients关键词
子宫内膜异位症/缺氧诱导因子-1αPTEN蛋白/免疫组化Key words
Endometriosis/ HIF-1 a/ PTEN/ Immunohistochemistry引用本文复制引用
王步军,郑飞云,杨孝军,张乾..HIF-1α和PTEN蛋白在异位子宫内膜中的表达及临床意义[J].浙江医学,2011,33(12):1777-1780,4.
