雌激素与去卵巢小鼠外周血T淋巴细胞亚群及免疫球蛋白关系的研究OACSTPCD
Effect of estradiol replacement on levels of peripheral blood T cell subsets and immunoglobulin in ovariectomized mice
目的 通过对去卵巢小鼠补充E2治疗,观察外周血T淋巴细胞亚群及免疫球蛋白水平变化,探讨E2对上述指标的影响.方法 60只健康雌性小鼠随机分为3组,假手术组不给药物,去卵巢小鼠分别接受苯甲酸雌二醇(用药组)及注射油(非用药组)皮下注射治疗,每周2次,共注射25次(12周),酶联免疫吸附法检测3组血清E2及免疫球蛋白(IgG、IgM、IgA)水平,流式细胞仪检测血CD4+ T细胞和CD8+T细胞变化.结果 (1)术后12 周用药组血CD8+T细胞数(…查看全部>>
To investigate the relationship between estradiol (E2 land the levels of peripheral T cell subsets and immunoglobulins in ovariectomized mice.MethodsSixty female mice were divided into 3 group at random: sham operation group, OVX+EB group and OVX group. In OVX+EB group ovariectomized mice were injected with estradiol twice a week for 25 times, in OVX group ovariectomized mice were treated with injection oil instead. The serum levels of E2 and immunoglobulin …查看全部>>
邵明君;何云芹; 胡旻;胡美旭;童月红;唐飞
321000,金华市中心医院妇产科321000,金华市中心医院妇产科321000,金华市中心医院妇产科321000,金华市中心医院妇产科321000,金华市中心医院妇产科321000,金华市中心医院妇产科
去卵巢雌激素T淋巴细胞免疫球蛋白
Ovariectomize Estradiol T lymphocyte Immunoglobulin
《浙江医学》 2011 (12)
1793-1795,3
金华市科技局项目(J 2008-3-030)
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