中国组织工程研究与临床康复2011，Vol.15Issue(53)：10068-10070,3.DOI:10.3969/j.issn.1673-8225.2011.53.046
肾移植后合并马尔尼菲青霉菌感染1例
One case of Penicillium marneffei infection after kidney transplantation
陈统清 1孔耀中 1罗绮雯 1林敏娃 1徐杰伟2
作者信息
- 1. 中山大学附属佛山市第一人民医院,肾内科,广东省佛山市,528000
- 2. 中山大学附属佛山市第一人民医院,检验科,广东省佛山市,528000
- 折叠
摘要
Abstract
BACKGROUND: Due to the application of immunos up press ants and broad-spectrum antibiotics after kidney transplantation,complicated infected pathogen emerges, illness becomes serious and death rate t high. Therefore, it is the key to improveinfection cure rate by racing awareness of pathogenic characteristics of rare bacteria combined after kidney transplantation andearly appropriate treatment.OBJECTP/E: To investigate the clinical characteristics and treatment of Penicillium marneffei infection afterkidneytransplantation.METHOOS: Clinical data, predisposing factors, pathogenic characteristics and treatment of one kidney transplantation patientwere analyzed retrospectnsely in June 2010.RESULTSAND CONCLUSION: Clinical manifestations with ehilb, fever, oliguria. abdominal distension, cough, sputum, weghtloss andfatigue lAiereshaAin in the patient. Blood routine examination: white blood celts (1.42-251)f?:itf/L. hemoglobin 66-S3 g'L,platelets (21-43)X1O9/L, C-reactive protein 179.0-212.0 mg/L. procalcitonin-u 17.2-28.9 ugfl_ The groutfh of Penicilium marnefreivuas shown in the chest, ascites and blood culture. Butthe symptoms were not improved after 250 mg/d intravenous infusion ofitraconazole, suspension of immunos up pressants and immune support with gamma globulin and thymes in. Eventualry, the patientgave up the treatment because of respiratory and circulatory failure. Clinical cases of Penicillium marneffei infection afterkidneytransplantation are rare, so the cinician have a Irttle understanding of it. Thus, there is in demand for a consideration to thePenicillium marneffei infection for patients who have extremely low immune function with recurrent fever and murtiple organdysfunctions. Biphasicfungal culture and antigen determination if permitted need to be done for early diagnosis.关键词
马尔尼菲青霉菌/肾移植/感染/免疫抑制剂/排斥反应分类
临床医学引用本文复制引用
陈统清,孔耀中,罗绮雯,林敏娃,徐杰伟..肾移植后合并马尔尼菲青霉菌感染1例[J].中国组织工程研究与临床康复,2011,15(53):10068-10070,3.
