中国组织工程研究与临床康复2011，Vol.15Issue(53)：9905-9908,4.DOI:10.3969/j.issn.1673-8225.2011.53.007
尿CD54+淋巴细胞在肾移植急性排斥反应中的变化
Changes of urine CD54+ lymphocytes in acute rejection after renal transplantation
李沙丹 1王亮 1王庆堂 1陈卫国 1杨航 1周鹏 1梁平 1李晓伟1
作者信息
- 1. 解放军成都军区总医院泌尿外科,四川省成都市,610083
- 折叠
摘要
Abstract
BACKGROUND: The expression of CD 54 is low in normal kidney, renal tubular epithelium andvascularendothelialcelfe.CD54expression in renal tubular epithelial celt; and vascular endothelial cells increases obviously when acute rejection occurres. In themeantime, the C054 express ion level in renal tubular epithelial cells increases along with interstitial renal edema and massiveleukocyte infiltration.OBJECT rVE: To assess the value of flow cytometer detection for urine CD54* lymphocytes in the diagnosis of a cute rejectionafter renal transplantation.METHODS: Participants were renal transplant recipients from General Hospital of Chengdu Military Area Command of ChinesePLA, including patients obtained normal renal function 07=13), patients with acute rejection f/r=8) and patients with graftdysfunction(n=9). Hearthy volunteers were included as control (i?=1O). Urine CD54* lymphocyte rates of each group werecompared by flow cytometer before and after transplantation.RESULTS ANO CONCLUSION: The expression of urine CDS^ rymphocytes in renal transplant recipients increased significantlyduring the rejective time (P < 0.01), and reduced gradualh/ after anti-rejction treatment. The expression of CD54 increasedmoderately in patients obtained normal renal function and patients with graft dysfunction. These findings indicate thatCD54*lymphocyte level in urine can accurately reflect the immune condition of renal transplant recipients and could be used as aspecific parameter in the diagnosis of acute rejection after renal transplantation.关键词
急性排斥反应/CD54/流式细胞仪/肾移植/尿液分类
临床医学引用本文复制引用
李沙丹,王亮,王庆堂,陈卫国,杨航,周鹏,梁平,李晓伟..尿CD54+淋巴细胞在肾移植急性排斥反应中的变化[J].中国组织工程研究与临床康复,2011,15(53):9905-9908,4.
