中国组织工程研究与临床康复2011，Vol.15Issue(51)：9587-9592,6.DOI:10.3969/j.issn.1673-8225.2011.51.021
Fe3O4纳米粒子的细胞相容性
Cellular compatibility of Fe3O4 nanoparticles
龚君佐 1屠重棋 2段宏 2周绍兵3
作者信息
- 1. 川北医学院急诊医学系,四川省南充市,637000
- 2. 四川大学华西医学中心骨科,四川省成都市,610046
- 3. 西南交通大学材料先进技术教育部重点实验室,四川省成都市,610046
- 折叠
摘要
Abstract
BACKGROUND: Whether as chemotherapy or as a medium of thermotherapy in malignant tumor, the effect and microstructure of Fe3O4 nanoparticles need further studies.OBJECTIVE: To analyze the cellular compatibility of Fe 3O4 nanoparticles and to investigate the application and problems of Fe3O4 nanoparticles as drug carriers in the chemotherapy of malignant bone tumors.METHODS: According to the evaluate criteria and requirement of GB/T 16886. 5-2003 (Part V: cytotoxicity test in vitro, Biological Evaluation for Medical Instrument), the colloidal solution of Fe 3O4 nanoparticles conjugated with cetrimonium bromide or polyethylene glycol or sodium oleate was co-cultured with osteosarcoma UMR-16 cells and human fibroblast cells, respectively,hence to assess the cytotoxicity characteristics.RESULTS AND CONCLUSION: According the criteria of GB/T16886.5-2003, Fe3O4 nanoparticles conjugated with sodium oleate had good cellular compatibility, whereas, the cellular compatibility of Fe3O4 nanoparticles conjugated with cetrimonium bromide was poor, which were not considered as a drug carrier of chemotherapy drug usi ng in clinical practice. Fe 3O4 nanoparticles conjugated with polyethylene glycol had a certain cellular compatibility, which needed further studies used as drug carriers.关键词
Fe3O4纳米粒子/细胞相容性/细胞毒性/药物载体/化疗分类
医药卫生引用本文复制引用
龚君佐,屠重棋,段宏,周绍兵..Fe3O4纳米粒子的细胞相容性[J].中国组织工程研究与临床康复,2011,15(51):9587-9592,6.
