中国组织工程研究与临床康复2011，Vol.15Issue(53)：9953-9956,4.DOI:10.3969/j.issn.1673-8225.2011.53.018
肾移植后的蛋白尿
Proteinuria after kidney transplantation
沈蓓莉 1杨磊 1胡俊杰 1王素静 1谢红梅 1郭晓芳1
作者信息
- 1. 郑州人民医院肾器官移植科,河南省郑州市,450003
- 折叠
摘要
Abstract
BACKGROUND: Proteinuria directly correlates with long-term survrval of transplanted kidney and e an in dependent risk factorinfluencing long-term survival of transplanted kidney and leading to death of transplant patients.OBJECT P/E: To investigate the effects of angiotensin D receptor blodter combined with tripterygium glycosides in treatment ofproteinuria after kidney transplantation.METHODS: Forty-five patients presenting with proteinuria after kidney transplantation were dwided into three groups: treatment.tripterygium glycosides group and control. In the treatment group, based on conventional application of immunosuppressiveagent, 2-fold dose of angiotensin D receptor blocker combined wrth tripterygium glycosides (1 mgd<g per day) were used. In thetripterygium glycosides group, tripterygium glycosides (1 mgjkg per day) was used. In the control group, onty immunosuppressnseagent was used.RESULTS AND CONCLUSION: At 12 months after treatment, 24-hour urine protein, ciclosporin A concentration. cidcepomAdosage were significantly louver in the treatment and tripterygium glycosides groups than in the control group (P < 0￡6). Aftertreatment, urea nitrogen and creatinine levels in the treatment group were significantly louver than those in the control andtripterygium glycosides groups (p < 0.05). These findings suggest that angiotensin G receptor blocker combined withtripterygium glycosides can obviousry decrease urine protein level after kidney and reduce immunosuppressh/e agent applicationdose, exhibiting a protective effect on transplanted kidney.关键词
肾移植/蛋白尿/血管紧张素Ⅱ受体阻断剂/雷公藤多苷/治疗分类
医药卫生引用本文复制引用
沈蓓莉,杨磊,胡俊杰,王素静,谢红梅,郭晓芳..肾移植后的蛋白尿[J].中国组织工程研究与临床康复,2011,15(53):9953-9956,4.
