中国组织工程研究与临床康复2011，Vol.15Issue(53)：9957-9960,4.DOI:10.3969/j.issn.1673-8225.2011.53.019
肾移植后外周血CD4+及CD8+T细胞亚群计数的临床意义
Clinical significance of CD4+ and CD8+ T cell subset counts in renal allograft recipients
熊海云 1张雷 2王立明 2赵闻雨 2袁清 2陈瑜 2周琳 3张玲珍 3朱有华2
作者信息
- 1. 解放军第九四医院泌尿外科,江西省南昌市,330002
- 2. 解放军第二军医大学长征医院,器官移植科,上海市,200003
- 3. 解放军第二军医大学长征医院,实验诊断科,上海市,200003
- 折叠
摘要
Abstract
BACKGROUND: In the clinic, the ratio of peripheral blood CD4 to CDS T cell subset counts determined byflowcytometry t>often used to reveal the relationship related to rejection or infection.OBJECTIVE: To investigate the value and significance of peripheral blood CD4* and CDS* T cell subset counts in patientssuffering from rejection or infection after renal transplantation.METHODS: C04* and CD8* T cell subset counts in 121 patients receding renal transplantation were determined by flowcytometry. According to disease condition, patients were assigned to normal group, acute rejection group and pulmonaryinfection group.RESULTS AMD CONCLUSION: There was no significant difference in CD 4* and CDS* T eel subset count between normal andacute rejection groups (f3 > 0.05). CD4* and CDS* T cell subset counts were significantly reduced in the pulmonary infectiongroup than in the normal group (P < 0.001). When infection was controlled and symptoms were improved, CD4* and CDS* T cellsubset counts we re significantly increased (P < 0.001). These findings suggest that CD4* and CDS* T cell subset counte can beused as a reference of immune state in renal allograft recipients, they are more valuable in considering patent wth infectionthan patients with rejection, and serial observation of CD4* and CDS* T cell subset counts may be very useful in optimizingtreatment.关键词
细胞亚群/肾移植/T细胞/排斥反应/感染分类
医药卫生引用本文复制引用
熊海云,张雷,王立明,赵闻雨,袁清,陈瑜,周琳,张玲珍,朱有华..肾移植后外周血CD4+及CD8+T细胞亚群计数的临床意义[J].中国组织工程研究与临床康复,2011,15(53):9957-9960,4.
