中国组织工程研究与临床康复2011，Vol.15Issue(53)：9969-9972,4.DOI:10.3969/j.issn.1673-8225.2011.53.022
雷公藤多苷对同系大鼠肺移植排斥反应的影响
Effect of tripterygium glycosides on pulmonary transplantation rejection of syngeneic rats
朴铁花 1谷月 2蔡鸿彦 1席中原1
作者信息
- 1. 吉林省中医药科学院内一科,吉林省长春市130021
- 2. 吉林大学第一医院呼吸科,吉林省长春市130021
- 折叠
摘要
Abstract
BACKGROUND: Tripterygium wirfordii is woodiness lianas of celastraceae and has been proved to possess immun(suppression. Tripterygium i/uitfordii can be used as immunomodulator after lung transplantation.OBJECTIVE: To study the inhibition of triptetygium gh/cosides against acute rejection after lung transplantation of rats and ife effect on the intercellular adhesion molecule 1 (ICAM-1) level and the number of activated T cells in the peripheral blood. METHODS: Fifty Sprague DsAiley rats were selected randomly and divided into 3 groups: the blank group, the cento! group and the treatment group. Normal rats were the blank group. Lung orthotopic transplantation model; were established by the modified "cuff-Ike" vessel anastomose technique in the rate of the control group and the treatment group. After surgery, the bbrfc group and the control group were irrigated the rat stomach with normal saline at 1 mL/d, while the treatment group was treated with tripterygium glycosides at 50 mg/Vg/d for 5 days.RESULTS AND CONCLUSION: The rejection grade of lung transplantation of the treatment group was significantly lower than that of the control group (P < 0.01): the number of CD25*T cells and the ICAM-1 level in the peripheral blood of the treatment group were higher compared wrth the blank group r]P < 0.05), and lower than those of the control group (P<0D5). Trpterygium gh/cosides may reduce the peripheral CD25*T cells and antagonize the ICAM-1 inlungtissues to inhibitthe acute rejection after lung transplant in rats.关键词
雷公藤/肺脏/移植/细胞间黏附分子/免疫排斥分类
医药卫生引用本文复制引用
朴铁花,谷月,蔡鸿彦,席中原..雷公藤多苷对同系大鼠肺移植排斥反应的影响[J].中国组织工程研究与临床康复,2011,15(53):9969-9972,4.
