中国组织工程研究与临床康复2011，Vol.15Issue(49)：9275-9278,4.DOI:10.3969/j.issn.1673-8225.2011.49.036
内源性神经干细胞治疗脊髓损伤
Endogenous neural stem cells for treatment of spinal cord injury
摘要
Abstract
BACKGROUND: Spinal cord injury is a serious neurological disease, and the life quality of spinal cord injury patients signricantly I declines. With the development of medical science, endogenous neural stem cells as a treatment strategy for spin a I cord injury have attracted widespread attention in recent years.OBJECTIVE: To summarize the activation and differentiation of endogenous neural stem cells, as well as the mechanism in , treating spinal cord injury. !METH ODS: A computer-bas ed online search of Wanfang databas e and PubMed database from January 2002 to March 2011 ' was performed for related articles about neural stem cells for treatment of spinal cord injury, with keywords of "endogenous neural stem cells, spinal cord injury, differentiation" in Chinese and in English, respectively, by screening titles and abstracts. The . Documents associated with endogenous neural stem cells for treatment of spinal cord injury were selected, and those published ( recently or in authoritative journals were preferred in the same field. Totally 340 articles were obtained in initial retrieval, and 20 < articles of them were chosen based on inclusion criteria.RESULTS AND CONCLUSION: Endogenous neural stem cells have unique advantages as a new treatment. They can not only , avoid the immune rejection and ethical issues, but also exist in adult individuals. Most endogenous neural stem cells can I differentiate into astrocytes and oligodendrocytes rather than neurons. More neural stem cells can differentiate into neurons through the regulation of signal transduction pathways, which plays an important role in the treatment of spinal cord injury. ,关键词
内源性神经干细胞/脊髓损伤/神经元/分化/综述分类
医药卫生引用本文复制引用
张诚,陈刚..内源性神经干细胞治疗脊髓损伤[J].中国组织工程研究与临床康复,2011,15(49):9275-9278,4.基金项目
国家自然科学基金(30960393,81160155) （30960393,81160155）
新疆维吾尔自治区科技攻关项(200633128(2)). （200633128(2）
