临床神经外科杂志2011，Vol.8Issue(6)：285-287,3.DOI:10.3969/j.issn.1672-7770.2011.06.002
CXCR4/CXCL12在原发中枢神经系统淋巴瘤中的表达及其意义
Expression of CXCR4/CXCL12 in primary central nervous system lymphomas and their clinical significance
摘要
Abstract
Objective To elucidate the relationship of the expression of chemokine receptor CXCR4 and its ligand CXCL12 in 5 cases of primary central nervous system lymphomas( PCNSL) and their clinical significance. Method The expression of chemokine receptor and its ligand in 5 cases of PCNSL and 10 normal brain tissues were investigated using immunohistochemical and reverse transcription polymerase chain reaction(RT-PCR) methods. Results Immunohistochemistry; Of the 5 PCNSLs, all specimens (100%) were positive for CXCR4 and CXCL12. Of the 10 normal brain tissues, all specimens (100% ) were positive for CXCL12, and none was positive for CXCR4. RT-PCR :Of the PCNSLs, all specimens expressed the RNA of CXCR4 and CXCL12. The specimens of normal brain tissue was only expressed the RNA of CXCL12. Conclusion Chemokine receptor CXCR4 and its ligand CXCL12 play important roles in the pathogenesis of primary central nervous system lymphoma.关键词
原发中枢神经系统淋巴瘤/免疫组织化学/RT-PCRKey words
PCNSL/immunohistochemistry/RT-PCR分类
医药卫生引用本文复制引用
谭卫国,冯鸣,吴庭枫,孙春明,邵忠,王中,周幽心,杜子威..CXCR4/CXCL12在原发中枢神经系统淋巴瘤中的表达及其意义[J].临床神经外科杂志,2011,8(6):285-287,3.基金项目
江苏省"科教兴卫工程"医学重点学科基金(XK200722) （XK200722）
