中德临床肿瘤学杂志（英文版）2012，Vol.11Issue(2)：63-66,4.DOI:10.1007/s10330-011-0921-5
hnRNP B1mRNA在非小细胞肺癌患者外周血中手术前后的表达变化及临床意义
The perioperative change and clinical significance of the expression level of peripheral blood hnRNP B1 mRNA in NSCLC patients
Jun Lu 1Jingmin Ding 2Jiashun Wang 2Wendong Wang2
作者信息
- 1. Department of Thoracic Surgery, The Second Hospital of Yichang, Yichang 443000, China
- 2. Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
- 折叠
摘要
Abstract
Objective: The aim of this study was to investigate the perioperative expression of the peripheral blood hnRNP B1 mRNA in non-small-cell lung cancer (NSCLC) patients and its clinical significance. Methods: Using real time FQ-RT-PCR, we detected the expression of peripheral blood hnRNP B1 mRNA in 30 NSCLC patients on preoperative d3 and postoperative d3, d5, and d10, respectively. Results: The ΔΔCt value of hnRNP B1 in NSCLC patients on preoperative d3 was significantly different from those on postoperative d5 and d10 (P = 0.00), but not different from postoperative d3 (P = 0.12). The ΔΔCt values of patients with squamous cell carcinoma were significantly different from those with other pathological types on preoperative d3 (P = 0.02) and postoperative d3 (P = 0.01). Whereas, the ΔΔCt values were not related to gender, pathological stage and lymph node metastasis (P > 0.05). ΔΔCt values in patients with different pathology classifications had no differences on postoperative d5 and d10 (P > 0.05). Conclusion: The expression of peripheral blood hnRNP B1 mRNA in NSCLC patients decreased gradually after operation, which may be used in assessment of the therapeutic efficacy of the operation and prognosis, and the monitor of the tumor recurrence. In addition, preoperative and early postoperative expression of peripheral blood hnRNP B1 mRNA in NSCLC patients may be related to pathological types.关键词
non small-cell lung cancer (NSCLC)/ heterogeneity ribonucleoprotein/ surgical therapyKey words
non small-cell lung cancer (NSCLC)/ heterogeneity ribonucleoprotein/ surgical therapy引用本文复制引用
Jun Lu,Jingmin Ding,Jiashun Wang,Wendong Wang..hnRNP B1mRNA在非小细胞肺癌患者外周血中手术前后的表达变化及临床意义[J].中德临床肿瘤学杂志（英文版）,2012,11(2):63-66,4.
