中德临床肿瘤学杂志（英文版）2012，Vol.11Issue(2)：72-75,4.DOI:10.1007/s10330-011-0896-2
CT/CT图像融合用于非小细胞肺癌放射治疗对V20及放射性肺炎影响的临床研究
Study of the impact of CT/CT image fusion radiotherapy on V20 and radiation pneumonitis of non-small cell lung cancer
Liang Liu 1Jinzhong Zhang 1Changhu Li 1Wei Ge 1Shunxiang Luo 1Yu Huang 1Yongfa Zheng1
作者信息
- 1. Center of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, China
- 折叠
摘要
Abstract
Objective: The aim of our study was to investigate the value of CT/CT image fusion radiation treatment planning in non-small cell lung cancer (NSCLC) and the impact on V20 and radiation pneumonitis (RP). Methods: Patients who were pathologically or cytologically diagnosed of stage IIIA and IIIB NSCLC were treated with three-dimensional conformal radiation therapy (4000 cGy). Forty patients got at least 25% tumor reduction were randomly divided into two groups: group A of regular shrink field radiotherapy (20 cases) and group B of CT/CT image fused shrink field radiotherapy (20 cases). Dosage reached 6600 cGy. Clinical data, V20 and RP were observed within 3 months after radiotherapy. Statistical analysis was conducted for the NSCLC patients. Results: 22.5% (9/40) patients got RP during follow-up. Group A accounted for 6 cases (30%), and group B had 3 cases (15%). There was no marked difference between the two groups (P = 0.256), univariate analysis revealed that the IV20 of A and B groups, and IV20 and CV20 of all patients were statistically related to the incidence of RP (P < 0.05). With Wilcoxon method assay, the ipsilateral lung V20 and contralateral lung V20 had statistical significance between the two groups (P < 0.05). Conclusion: The CT/CT image infusion treatment planning could increase the radical dosage with better tumor control probability but won't increase adverse reaction.关键词
non-small cell lung cancer/ three-dimensional conformal radiation therapy/ radiation pneumonitis/ CT/CT image fusion/ V20Key words
non-small cell lung cancer/ three-dimensional conformal radiation therapy/ radiation pneumonitis/ CT/CT image fusion/ V20引用本文复制引用
Liang Liu,Jinzhong Zhang,Changhu Li,Wei Ge,Shunxiang Luo,Yu Huang,Yongfa Zheng..CT/CT图像融合用于非小细胞肺癌放射治疗对V20及放射性肺炎影响的临床研究[J].中德临床肿瘤学杂志（英文版）,2012,11(2):72-75,4.
