中德临床肿瘤学杂志（英文版）2012，Vol.11Issue(2)：76-79,4.DOI:10.1007/s10330-011-0894-4
肺腺癌神经内分泌分化的临床意义
Clinical relevance of neuroendocrine differentiation in lung adenocarcinoma
Yuanhuan Dong 1Leina Sun 2Baocun Sun 2Dongxiang Yu 1Zhongli Zhan2
作者信息
- 1. Department of Pathology, Ninghe County Hospital, Tianjin 301500, China
- 2. Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
- 折叠
摘要
Abstract
Objective: The aim of our study was to investigate the prevalence and clinical relevance of neuroendocrine (NE) differentiation in lung adenocarcinoma. Methods: Eighty-six adenocarcinoma paraffin-embedded specimens and cases which were followed up completely for 3 years, were obtained from 86 patients (35 men and 51 women) who underwent surgical resection for pathologically supported adenocarcinoma in the Cancer Hospital of Tianjin Medical University, from June 2005 to December 2006. Immunohistochemical EnVision two-step method was used to detect the expression of neuron-specific enolase (NSE), synaptophysin (SYN) and chromogranin A (CGA). All data were analyzed using SPSS statistics software and Kaplan-Meier survival curves were constructed, meanwhile, we conducted a Log-rank test. Results: All patients with lung adenocarcinoma, 35 cases with NE differentiation (40.7%). The statistical analysis showed that the positive rate of NE differentiation in lung adenocarcinoma was significantly associated with cancer recurrence and histological differentiation. In addition, CGA, NSE and SYN positive rates were 27.9%, 50.0%, 43.0%, respectively. A statistically significant difference was found between positive expression of SYN and other clinicopathological parameters, such as pathological type, histological differentiation, lymph node metastasis, postoperative recurrence and 3-year survival rate (P = 0.001) and so on. Conclusion: NE differentiation can be used as a metastatic potentially indicator of biological behavior of lung adenocarcinoma, and combined detection of NSE and SYN markers may be recommended to examine NE differentiation of lung adenocarcinoma. Positive expression of SYN indicates poor prognosis.关键词
lung adenocarcinoma/ neuroendocrine differentiation/ biological behavior/ prognosisKey words
lung adenocarcinoma/ neuroendocrine differentiation/ biological behavior/ prognosis引用本文复制引用
Yuanhuan Dong,Leina Sun,Baocun Sun,Dongxiang Yu,Zhongli Zhan..肺腺癌神经内分泌分化的临床意义[J].中德临床肿瘤学杂志（英文版）,2012,11(2):76-79,4.
