广西医学2012，Vol.34Issue(1)：1-3,3.
HBV-M表达模式和HBV-DNA定量与原发性肝癌的关系研究
An Investigation of the Relationship between the Development of Hepatocellular Carcinoma and the Expression Model of Hepatitis B Virus Serological Markers or the Level of HBV-DNA
摘要
Abstract
Objective To explore the relationship between the development of hepatocellular carcinoma and the expression model of hepatitis B virus serological markers( HBV-M )or the replication level of hepatitis B virus DNA ( HBV-DNA ). Methods 216 cases of hepatocellular carcinoma were enrolled as case group( HCC group ), and 353 patients with chronic HBV infection as the control group( CHB group ), Enzyme-linked immunosorbent assay( ELJSA ) and polymerase chain reactiongroup( PCR )were used to detect the HBV-M and the replication level of HBV-DNA respectively. Results The rate of the model( HBsAg, HBeAb, HBcAb positive, STP )was 62.04% and 61.47% in the case group and the control group respectively( P > 0. 05 ), while the rate of the model( HBsAg, HBeAg, HBcAb positive,LTP )was 18.98% and 36. 83% in the case group and the control group respectively( P >0.05 ). The rate of the model STP was significantly higher than the rate of the model LTP in the case group( P >0.05 ),but there was no significant difference in the control group. The rate of the model LTP in CHB group was also higher than that in HCC group( P <0.05 ). Positive rates of HBV-DNA in the patients with HCC and the patients with chronic HBV infection were 56.5% and 79% respectively. The replication level of HBV-DNA in HCC group( 4.99 ± 1.02 )was significantly lower than that( 5. 80 ± 1. 43 )of CHB group( P < 0. 05 ). Conclusion The expression model of HBsAg, HBeAb, HBcAb in patients with hepatocellular carcinoma is given priority to the patients with chronic HBV-infection, and the replication level of HBV-DNA of hepatocellular carcinoma is significantly lower than that of chronic HBV infection.关键词
原发性肝癌/HBV-M/HBV-DNAKey words
Hepatocellular carcinoma/ Hepatitis B virus serological markers/ Hepatitis B virus DNA分类
医药卫生引用本文复制引用
陈务卿,吴继周,宁秋悦,玉艳红,韦科利..HBV-M表达模式和HBV-DNA定量与原发性肝癌的关系研究[J].广西医学,2012,34(1):1-3,3.基金项目
国家自然科学基金(30960170) （30960170）
广西医疗卫生科研课题(重200849) （重200849）
