广西医学2012，Vol.34Issue(1)：4-7,4.
MMP-9、nm23在广西食管癌患者中的表达及其相关性研究
Expression of MMP-9 and nm23 in Esophageal Cancer in Guangxi and Their Correlation with Clinicopathological Factors
摘要
Abstract
Objective To investigate the level of matrix metallo proteinase-9( MMP-9 )and non-metastasis 23 ( nm23 )expression in esophageal cancer and normal esophageal mucosa in Guangxi,and detect their relationships with clinical predictive indicators. Methods The levels of MMP-9 and nm23 expression in 80 cases of esophageal cancer and 10 cases of normal esophageal mucosa were detected by SP immunohistochernical method. Results MMP-9 positive expression rate in esophageal cancer was significantly higher than that of normal esophageal mucosa( P < 0.05 ). MMP-9 positive expression rate had no significant correlation with the patients' age,sex,and histological type( P >0.05 ),but had correlation with degree of the differentiation,tumors invade depth,clinical stag,and lymph node metastasis( P <0.05 ). Nm23 positive expression in esophageal cancer was significantly lower than that of normal esophageal mucosa( P <0.05 ),and it had no significant correlation with the patients' age,sex,histological type,degree of the differentiation,and tumors invade depth( P >0.05 ), but had correlation with lymph node metastasis and clinical stag( P < 0. 05 ). MMP-9 had negative correlation with nm23( P <0.05 ). Conclusion MMP-9 is involved in the occurrence,invasion,metastasis of esophageal cancer in Cuangxi,and expression loss of nm23 is closely correlated with the occurrence of esophageal cancer,which can be taken as an evaluation index of esophageal cancer. Mutual inhibition between MMP-9 and nm23 occurs when they involve in the presence of esophageal cancer.关键词
食管癌/MMP-9/nm23/免疫组织化学/广西Key words
Esophageal cancer/Matrix metallo proteinase-9/Non-metastasis 23/Immunohistochemistry/Guangxi分类
医药卫生引用本文复制引用
苏乃伟,冯旭,覃家锦..MMP-9、nm23在广西食管癌患者中的表达及其相关性研究[J].广西医学,2012,34(1):4-7,4.基金项目
广西自然科学基金(桂科青0640047) （桂科青0640047）
广西大型仪器网测试资助项目 （）
