中国病理生理杂志2012，Vol.28Issue(1)：152-154,158,4.DOI:10.3969/j.issn.1000-4718.2012.01.029
STAT3和SOCS3与子宫内膜异位症的相关性研究
Relationship between STAT3/SOCS3 and endometriosis
摘要
Abstract
AIM:To analyze the relationship between the expression of signal transducer and activator of transcription3 ( STAT3 ) and suppressor of cytokine signaling3 ( SOCS3 ),and endometriosis. METHODS:Ectopic ( ectopic group, n = 30 ) and eutopic endometrial tissues ( eutopic group, n = 30 ) were obtained from the women with histopathologically confirmed endometriosis. Normal endometrial tissues ( control group, re =25 ) were collected from the women without endometriosis. Western blotting analysis was used to assess the protein expression of SOCS3, total STAT3 and its activated form phosphorylated STAT3. RESULTS: No significant difference of total STAT3 protein level among the 3 groups was observed, while the level of p - STAT3/STAT3 ( representing the activating extent) was significantly higher in ectopic group than that in control group and eutopic group. Expression of SOCS3 protein was opposite to the activation level of STAT3. Negative correlation was showed between the activation level of STAT3 and the expression of SOCS3 protein ( r = - 0.499, P < 0. 01 ) in the patients with endometriosis. CONCLUSION: Activation of STAT3 is higher in the ectopic endometrium of endometriosis patients than that in the patients with eutopic endometrium and controls, which is negatively correlated with the expression of SOCS3 protein, indicating that dysregulation of STAT3 activation and SOCS3 expression may participate in the pathogenesis and progression of endometriosis.关键词
子宫内膜异位症/信号转导与转录活化因子/3/细胞因子信号抑制因子/3Key words
Endometriosis/Signal transducer and activator of transcription 3/Suppressor of cytokine signaling -3分类
医药卫生引用本文复制引用
涂飞霞,阮菲,吴瑞瑾,詹宏,马俊彦,林俊..STAT3和SOCS3与子宫内膜异位症的相关性研究[J].中国病理生理杂志,2012,28(1):152-154,158,4.基金项目
国家自然科学基金资助项目(No.81170546) （No.81170546）
浙江大学博士点基金资助项目(No.20090101110123) （No.20090101110123）
