中国神经再生研究（英文版）2012，Vol.7Issue(1)：61-65,5.DOI:10.3969/j.issn.1673-5374.2012.01.010
Chondroitinase ABC improves recovery of long sciatic nerve defects
Chondroitinase ABC improves recovery of long sciatic nerve defects
摘要
Abstract
Sciatic nerves from allogeneic Sprague-Dawley rats were pretreated with chondroitinase ABC and were used to bridge damaged sciatic nerves in Wistar rats. Chondroitin sulfate proteoglycans were removed from the chemically extracted acellular nerves. At 3 months after grafting, the footplate pinch test result was positive in the Wistar rats. Autotomy scores decreased, and increased muscular contraction tension appeared when triceps surae muscles were stimulated. In addition, the recovery rate of wet triceps surae muscle weight increased, and the distal segment of the chondroitinase ABC-treated graft exhibited Schwann cells next to the nerve fibers. These results suggested that chondroitinase ABC pretreatment enhanced repair of long nerve defects via acellular nerve grafting.关键词
chondroitinase ABC/neural regeneration/peripheral nerve/sciatic nerve/Schwann cellKey words
chondroitinase ABC/neural regeneration/peripheral nerve/sciatic nerve/Schwann cell引用本文复制引用
Hailong Yu,Liangbi Xiang,Wenjing Xu,Bin Zhao,Yu Wang,Jiang Peng,Shibi Lu..Chondroitinase ABC improves recovery of long sciatic nerve defects[J].中国神经再生研究（英文版）,2012,7(1):61-65,5.基金项目
This study was funded by the Liaoning Scientific Research Foundation of Doctor,No.20101134 （）
and the Beijing Natural Science Foundation (The oriented micro-structure,double-aligned nerve-derived extracellular matrix scaffolds promote peripheral nerve long defects regeneration). （The oriented micro-structure,double-aligned nerve-derived extracellular matrix scaffolds promote peripheral nerve long defects regeneration）
