中国神经再生研究（英文版）2012，Vol.7Issue(2)：125-130,6.DOI:10.3969/j.issn.1673-5374.2012.02.008
Dynamic expression of cerebral cortex and hippocampal glutamate transporters in a rat model of chest compression-induced global cerebral ischemia
Dynamic expression of cerebral cortex and hippocampal glutamate transporters in a rat model of chest compression-induced global cerebral ischemia
Qinhua Guo 1Jin Lan 1Weiqiao Zhang 1Pin Guo 1Liemei Guo 1Zhiqiang Li 2Yongming Qiu1
作者信息
- 1. Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
- 2. Central Hospital of Fengxian District, Shanghai Neurological Research Institute of Anhui University of Science & Technology, Shanghai 201400, China
- 折叠
摘要
Abstract
The present study established a rat model of global cerebral ischemia induced by chest compression for six minutes to dynamically observe expressional changes of three glutamate transporters in the cerebral cortex and hippocampus. After 24 hours of ischemia, expression of glutamate transporter-1 significantly decreased in the cerebral cortex and hippocampus, which was accompanied by neuronal necrosis. At 7 days post-ischemia, expression of excitatory amino acid carrier 1 decreased in the hippocampal CA1 region and cortex, and was accompanied by apoptosis. Expression of glutamate-aspartate transporter remained unchanged at 6 hours-7 days after ischemia. These results suggested that glutamate transporter levels were altered at different periods of cerebral ischemia.关键词
apoptosis/excitatory amino acid carrier 1/global cerebral ischemia/glutamate- aspartate transporter/glutamate transporter/glutamate transporter-1/neuroprotectionKey words
apoptosis/excitatory amino acid carrier 1/global cerebral ischemia/glutamate- aspartate transporter/glutamate transporter/glutamate transporter-1/neuroprotection引用本文复制引用
Qinhua Guo,Jin Lan,Weiqiao Zhang,Pin Guo,Liemei Guo,Zhiqiang Li,Yongming Qiu..Dynamic expression of cerebral cortex and hippocampal glutamate transporters in a rat model of chest compression-induced global cerebral ischemia[J].中国神经再生研究（英文版）,2012,7(2):125-130,6.
