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Calcium channel blockers and Alzheimer's disease

Yi Tan Yulin Deng Hong Qing

中国神经再生研究(英文版)2012,Vol.7Issue(2):137-140,4.
中国神经再生研究(英文版)2012,Vol.7Issue(2):137-140,4.DOI:10.3969/j.issn.1673-5374.2012.02.010

Calcium channel blockers and Alzheimer's disease

Calcium channel blockers and Alzheimer's disease

Yi Tan 1Yulin Deng 1Hong Qing1

作者信息

  • 1. School of Life Science, Beijing Institute of Technology, Beijing 100081, China
  • 折叠

摘要

Abstract

Alzheimer's disease is characterized by two pathological hallmarks: amyloid plaques and neurofi-brillary tangles. In addition, calcium homeostasis is disrupted in the course of human aging. Recent research shows that dense plaques can cause functional alteration of calcium signals in mice with Alzheimer's disease. Calcium channel blockers are effective therapeutics for treating Alzheimer's disease. This review provides an overview of the current research of calcium channel blockers in-volved in Alzheimer's disease therapy.

关键词

Alzheimer's disease/calcium channel/calcium homeostasis/Alzheimer's disease pathogenesis/β-amyloid/calcium channel blocker

Key words

Alzheimer's disease/calcium channel/calcium homeostasis/Alzheimer's disease pathogenesis/β-amyloid/calcium channel blocker

引用本文复制引用

Yi Tan,Yulin Deng,Hong Qing..Calcium channel blockers and Alzheimer's disease[J].中国神经再生研究(英文版),2012,7(2):137-140,4.

中国神经再生研究(英文版)

OACSCDCSTPCDSCI

1673-5374

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