首页|期刊导航|中国神经再生研究（英文版）|Sericin can reduce hippocampal neuronal apoptosis by activating the Akt signal transduction pathway in a rat model of diabetes mellitus
中国神经再生研究（英文版）2012，Vol.7Issue(3)：197-201,5.DOI:10.3969/j.issn.1673-5374.2012.03.007
Sericin can reduce hippocampal neuronal apoptosis by activating the Akt signal transduction pathway in a rat model of diabetes mellitus
Sericin can reduce hippocampal neuronal apoptosis by activating the Akt signal transduction pathway in a rat model of diabetes mellitus
摘要
Abstract
In the present study, a rat model of type 2 diabetes mellitus was established by continuous peritoneal injection of streptozotocin. Following intragastric perfusion of sericin for 35 days, blood glucose levels significantly reduced, neuronal apoptosis in the hippocampal CA1 region decreased, hippocampal phosphorylated Akt and nuclear factor kappa B expression were enhanced, but Bcl-xL/Bcl-2 associated death promoter expression decreased. Results demonstrated that sericin can reduce hippocampal neuronal apoptosis in a rat model of diabetes mellitus by regulating abnormal changes in the Akt signal transduction pathway.关键词
sericin/type 2 diabetes mellitus/hippocampus/apoptosis/Akt signal transduction pathway/neural regenerationKey words
sericin/type 2 diabetes mellitus/hippocampus/apoptosis/Akt signal transduction pathway/neural regeneration引用本文复制引用
Zhihong Chen,Yaqiang He,Chengjun Song,Zhijun Dong,Zhejun Su,Jingfeng Xue..Sericin can reduce hippocampal neuronal apoptosis by activating the Akt signal transduction pathway in a rat model of diabetes mellitus[J].中国神经再生研究（英文版）,2012,7(3):197-201,5.基金项目
This study was supported by a grant from the Education Department of Hebei Province (Mechanism of GH/IGF-1 and protective effects of sericin on gonadal axis lesions in diabetes mellitus),No.2006301 （Mechanism of GH/IGF-1 and protective effects of sericin on gonadal axis lesions in diabetes mellitus）
a grant from Science and Technology Department of Hebei Province(Protective effects of sericin on testicular dysfunctionin diabetes mellitus),No.08276101D-19 （Protective effects of sericin on testicular dysfunctionin diabetes mellitus）
