中国神经再生研究（英文版）2012，Vol.7Issue(3)：202-206,5.DOI:10.3969/j.issn.1673-5374.2012.03.008
Protective effects of Purendan superfine powder on retinal neuron apoptosis in a rat model of type 2 diabetes mellitus
Protective effects of Purendan superfine powder on retinal neuron apoptosis in a rat model of type 2 diabetes mellitus
Zhijun Dong 1Xiangyi Tao 1Xiaoxiao Fu 1Haibin Wang 1Donghua Wang 1Tiemin Zhang1
作者信息
- 1. Department of Ophthalmology, Chengde Medical College Affiliated Hospital, Chengde 067000, Hebei Province, China
- 折叠
摘要
Abstract
This study sought to investigate the effects of Purendan superfine powder comprised of Momordica charantia, Radix Ginseng, and Radix Salviae Miltiorrhiae on neuronal apoptosis and expression of bcl-2, bax, and caspase-3, which are retinal apoptosis-associated factors in rats with diabetes mellitus induced by continuous intraperitoneal injection of streptozotocin. The results showed that Purendan superfine powder could upregulate the expression of bcl-2 protein and mRNA, and downregulate the expression of bax and caspase-3 in the retina of diabetes mellitus rats. In addition, Purendan superfine powder was shown to reduce the number of apoptotic neurons. Our experimental findings indicate that Purendan superfine powder can inhibit neuronal apoptosis in the retina of diabetes mellitus rats and has protective effects on diabetic retinopathy.关键词
Purendan superfine powder/diabetic retinopathy/bcl-2/bax/caspase-3/cellular apoptosiszhangtiemin1956@126.comKey words
Purendan superfine powder/diabetic retinopathy/bcl-2/bax/caspase-3/cellular apoptosiszhangtiemin1956@126.com引用本文复制引用
Zhijun Dong,Xiangyi Tao,Xiaoxiao Fu,Haibin Wang,Donghua Wang,Tiemin Zhang..Protective effects of Purendan superfine powder on retinal neuron apoptosis in a rat model of type 2 diabetes mellitus[J].中国神经再生研究（英文版）,2012,7(3):202-206,5.
