广东医学2012，Vol.33Issue(2)：164-166,3.
益肾汤对糖尿病大鼠肾脏细胞周期调节蛋白p27表达的影响
Effects of Yishentang on cell cycle regulatory protein p27 in the kidney of diabetic rats
摘要
Abstract
Objective To observe the effect of Yishentang ( a compound of traditional Chinese medicine ) on the expression of p27 in the kidney of diabetic rats. Methods Forty - one adult male SD rats were randomly divided into four groups: normal control group ( CON ), diabetic control group ( DMN ), diabetic group treated with Valsartan ( VST ), and diabetic group treated with YISHENTANG ( YST ). The diabetic rats were induced by single peritoneal injection of STZ of 60 mg/kg. Rats in YST group were treated with YISHENTANG 6. 5 g/kg daily, in VST with Valsartan 20 mg/kg daily, while equivalent drinking water was applied as substitute in CON and DMN groups. After 8 weeks, the body weight, plasma glucose, urea nitrogen, 24 h urine total proteins, 24 hours urine albumin protein and the renal expression of p27 were recorded. Results Diabetes was successfully induced. Significant down - regulation of renal p27 and reduction of 24 hours urine albumin protein were revealed in YST and VST groups, as compared with those in DMN group. The renal expression of p27 was significantly positive correlated with 24 hours urine albumin protein. Conclusion The preventive effects of YISHENTANG on diabetic nephropathy are correlated with down - regulation of renal p27.关键词
糖尿病肾病/益肾汤/细胞周期调节蛋白p27Key words
diabetic nephropathy/ Yisentang/ Cell cycle relatory protein p27引用本文复制引用
张一萍,朱俊,陈澍..益肾汤对糖尿病大鼠肾脏细胞周期调节蛋白p27表达的影响[J].广东医学,2012,33(2):164-166,3.基金项目
广州市中医药、中西医结合科研课题资助项目(编号:穗卫中[2009]4号-40) （编号:穗卫中[2009]4号-40）
