hEXO1A238G基因多态性与宫颈癌的易感相关性研究OA北大核心CSCDCSTPCD
Association analysis between the hEXO1 A238G polymorphism and the susceptibility of cervical cancer
目的 探讨hEXO1基因多态性与广东汉族妇女宫颈癌易感的相关性.方法 采用分子流行病学研究方法,收集123例经病理学确诊为宫颈癌的新发患者为病例组,274例年龄相匹配的健康妇女作为对照组;采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)分析技术,对hEXO1基因A238G多态位点进行分型,采用非条件logistic回归分析统计该多态位点与宫颈癌易感的相关性.结果 病例组与对照组间基因型频率分布差异无统计学意义(2=0.318,P=0…查看全部>>
Objective To investigate the correlation between the hEXO1 A238G polymorphism and susceptibility of cervical cancer in Cantonese Han population. Methods The genotypes of the hEXOl A238G polymorphism were determined in 123 cervical cancer patients and 274 healthy female blood donors by polymerase chain reaction - based restriction fragment length polymorphism ( PCR - RFLP ). Correlation between the polymorphism and susceptibility of cervical cancer was evalua…查看全部>>
洪小山;曾俐琴;罗喜平;熊兴东;李贞;刘新光;郭雪贞
广东省妇幼保健院妇科,广州,510010广东省妇幼保健院妇科,广州,510010广东省妇幼保健院妇科,广州,510010广东医学院衰老研究所,广东东莞,523808广东省妇幼保健院妇科,广州,510010广东医学院衰老研究所,广东东莞,523808广东省妇幼保健院妇科,广州,510010
hEXO1宫颈癌单核苷酸多态性遗传易感性
hEXO1 cervical cancer single nucleotide polymorphism genetic susceptibility
《广东医学》 2012 (2)
188-191,4
广东省医学科研基金资助项目(编号:A2010068)
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