安徽中医学院学报2012，Vol.31Issue(1)：51-54,4.DOI:10.3969/j.issn.1000-2219.2012.01.015
肠益康汤对脾虚泄泻小鼠肠道功能的保护作用
Protective Effects of Changyikang Decoction on Intestinal Function in Mice with Spleen Deficiency Induced Diarrhea
李华 1龙亚秋 2彭娟 3魏蕾初 3邓虹珠 3姚锐 3焦河玲3
作者信息
- 1. 南方医科大学南方医院药剂科,广东,广州,510515
- 2. 广东省中医院芳村分院急诊科,广东,广州,510370
- 3. 南方医科大学中医药学院,广东,广州,510515
- 折叠
摘要
Abstract
Objective To investigate regulative actions of Changyikang Decoction, a traditional Chinese medicine prescription, against the imbalance of intestinal flora and gastrointestinal dysfunctions in mice with spleen deficiency . Methods The mouse mode of spleen deficiency induced diarrhea was induced by intragastric injection of thubarb decoction. The mice with spleen deficiency were continuously given Changyikang Decoction via intragastric injection for 14 days. The intestinal flora was detected by using microscopy.The propulsion rate of ink in the intestine was observed by ink imprinting method. The histomorphological changes of intestinal mucosa were observed using transmission electron microscope. Results Compared with those in the model group, the amount of bifidobacterium and lactobacillus significantly increased in high-, middle- and low-dose Changyikang Decoction treated groups ( P＜0. 05 ) , and the propulsion rate of ink in the intestine significantly decreased in high- and middle-dose Changyikang Decoction treated groups ( P＜0. 05 ) , and the pathological changes of mouse intestinal mocosa were significantly alleviated in high-, middle- and low-dose Changyikang Decoction treated groups. Conclusion Changyikang Decoction can adjust the imbalance of intestinal flora,inhibit the propulsion movement of the intestine, and alleviate pathological changes of intestinal mucosa in mice with thubarb induced spleen deficiency.关键词
肠益康汤/肠道菌群/脾虚泄泻/小肠蠕动Key words
Changyikang Decoction/intestinal flora/ diarrhea due to spleen deficiency/ small intestine peristalsis分类
临床医学引用本文复制引用
李华,龙亚秋,彭娟,魏蕾初,邓虹珠,姚锐,焦河玲..肠益康汤对脾虚泄泻小鼠肠道功能的保护作用[J].安徽中医学院学报,2012,31(1):51-54,4.
