畜牧兽医学报2011，Vol.42Issue(1)：124-130,7.
桦木酸对小鼠淋巴细胞及巨噬细胞的影响分析
Effects of Betulinic Acid on Lymphocyte and Macrophage in Mice
摘要
Abstract
This study aimed to observe the effects of betulinic acid (BA) on the lymphocyte and macrophage in mice. BA was synthesized by oxidizing betulin from the bark of the white birth with Jone s reagent, followed by selective oxidation of the resulting betulonic acid with NaBH4. 168 KM mice (6 weeks old) were orally administered the BA for 14 days with the dose of 0, 0. 25, 0. 5 and 1 mg · kg-1 body weight. The effect of BA on the lymphocytes proliferation, thymocyte and splenocyte subsets, the number of plaque forming cells (PFC) and the phagocytic activity of the macrophages were evaluated. Oral administration of BA was found to significantly increase the thymus and spleen indices, lymphocytes proliferation induced by Concanavalin A or lipopolysaccharide, the percentage of CD4+ cells in thymus as well as the percentage of CD19+ B cells and the ratios of CD4+ /CD8+ cells in spleens. The number of PFC and the macrophage phagocytic activity was also enhanced. The results suggest that BA enhances mouse cellular immunity, humoral immunity, and activity of macrophages.关键词
桦木酸/淋巴细胞/巨噬细胞Key words
betulinic acid/ lymphocyte/ macrophage分类
农业科技引用本文复制引用
易金娥,袁莉芸,文利新,B Obminska-Mrukowicz,袁慧..桦木酸对小鼠淋巴细胞及巨噬细胞的影响分析[J].畜牧兽医学报,2011,42(1):124-130,7.基金项目
湖南省教育厅资助项目(08C433) （08C433）
湖南省研究生创新项目(14) （14）
