疑难病杂志2012，Vol.11Issue(2)：107-109,3.DOI:10.3969/j.issn.1671-6450.2012.02.012
糖耐量异常患者外周血管损害及高敏C反应蛋白、纤维蛋白原变化的临床研究
Study on peripheral arterial damage and plasma fibrinogen, serum high sensitivity C reactive protein level in patients with impaired glucose tolerance
袁公贤 1王桦 1汪迎晖 2刘珍丽 1夏上1
作者信息
- 1. 430071,武汉大学中南医院综合科
- 2. 430071,武汉大学中南医院超声影像科
- 折叠
摘要
Abstract
Objective To investigate the changes between the levels of plasma Fib, high sensitivity C reactive protein ( hs-CRP ) and the degree of peripheral arterial injury in impaired glucose tolerance ( IGT ) group. Methods 116 subjects were divided into IGT group( re =52 ) and control group ( healthy subjects, n =64). Fib and hs-CRP were detected by blood biochemistry analyzer and coagulometer respectively, the baPWV, ABI were measured by non-invasive automatic waveform ana-lyzer. Results The mean baPWV ( cm/s ) value was higher in IGT group than that in the control group ( 1564. 83 ±223. 24 vs 1477. 68 ± 194.78, P <0. 05 ). The mean ABI value in the IGT group was significantly lower than that in the control group ( 1. 12 ± 0. 13 vs 1. 18 ± 0. 17, P < 0. 05 ), and the levels of hs-CRP( mg/L ) and Fib( g/L ) were also higher than that in the control group( 1.37 ±0.50 vs 1. 12 ±0.35, P <0.01;2.95 ±0.52 vs 2.46 ±0.37, P <0.01 ); further analysis demonstrated that once the levels of baPWV was more than 1400 cm/s, the levels of the hs-CRP( mg/L ) and Fib( g/L ) in the IGT group were higher than those in the control group ( 1. 72 ± 0. 52 vs 1. 26 ± 0. 57, P < 0. 01; 3. 32 ± 0. 63 vs. 2. 60 ± 0. 60, P < 0. 01 ). Conclusion It proved that the patients with IGT suffered from vascular injury, combined with the increase of the levels of hs-CRP and Fib.关键词
糖耐量异常/并发症/脉搏波传导速度/踝-臂指数Key words
Impaired glucose tolerance/ Complication/ Pulse wave velocity/ Ankle-brachial index引用本文复制引用
袁公贤,王桦,汪迎晖,刘珍丽,夏上..糖耐量异常患者外周血管损害及高敏C反应蛋白、纤维蛋白原变化的临床研究[J].疑难病杂志,2012,11(2):107-109,3.
