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MicroRNA在大鼠心肌缺血再灌注损伤中表达谱的变化

谭健肖健王志农

实用医学杂志2012，Vol.28Issue(2)：199-201,3.

实用医学杂志2012，Vol.28Issue(2)：199-201,3.DOI:10.3969/j.issn.1006-5725.2012.2.013

MicroRNA在大鼠心肌缺血再灌注损伤中表达谱的变化

Changes of the expression profile of microRNAs in myocardium of rats with ischemia reperfusion injury

谭健 ¹肖健 ²王志农²

作者信息

1. 100700,北京军区总医院胸外科
2. 200433,上海市,第二军医大学附属长海医院
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摘要

Abstract

Objective To investigate the changes of the expression profile of microRNAs in myocardium of rats with ischemia reperfusion injury. Methods The expression profiles of microRNA in normal myocardium and ischemia reperfusion injured myocardium of rats were detected by microRNA genetic chip, and were verified by real-time quantitative PCR. Results As compared with normal myocardium, 10 microRNAs : rno-microRNA-21, rno-microRNA-26b, rno-microRNA-499, rno-microRNA-126, rno-let-7e, rno-microRNA-23a, rno-microRNA-23b, rno-let-7a, rno-let-7d, and rno-microRNA-26a were up-regulated, and 6 microRNAs : rno-microRNA-214, rno-microRNA-125b-5p, rno-microRNA-1, rno-microRNA-133a, rno-microRNA-133b, and rno-microRNA-24 were down-regulated in the ischemia reperfusion injured myocardium. Conclusions Ischemia reperfusion injury is associated with the change of the expression profile of microRNAs.

关键词

再灌注损伤/microRNA微阵列/微小RNA

Key words

Reperfusion injury/ MiRNA microarray/ MiRNA

引用本文复制引用

谭健,肖健,王志农..MicroRNA在大鼠心肌缺血再灌注损伤中表达谱的变化[J].实用医学杂志,2012,28(2):199-201,3.

实用医学杂志

OA北大核心CSTPCD

ISSN：1006-5725

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