实用医学杂志2012，Vol.28Issue(2)：221-223,3.DOI:10.3969/j.issn.1006-5725.2012.2.020
N端脑钠肽前体及基质金属蛋白酶-9与冠心病的相关性研究
Study of the association of NT-proBNP and MIVlP-9 levels with the extent of coronary artery disease
摘要
Abstract
Objective To study the association of N-terminal pro-brainnatriuretic peptide (NT-proBNP) and matrixmetalloproteinase-9 (MMP-9) levels and the extent of coronary artery disease CAD. Methods 91CAD patients and 30 non-CAD patients (Control group) were included in this study.All of the subjects were verified with coronary angiography.In the light of the types of CAD ,CAD patients were assigned into three groups (SAP group, UAP group and AMI group). The comparisons of NT-proBNP and MMP-9 levels were performed among the SAP , UAP,AMI and Control groups. The correlations of the number of impaired coronary arteries (CA), left main coronary stenosis and Gensini scores of CA with levels of NT-proBNP and MMP-9 were compared between 4 groups. Results We found a significant association between the types of CAD and changes of NT-proBNP or MMP-9 levels. We also observed that change of NT-proBNP or MMP-9 was significantly associated with the number of vessels of suffered CA. Conclusion There exists a certain correlation between the impaired CA and the plasma levels of NT-proBNP and MMP-9 which reflects the impairment of myocardium.关键词
冠心病/N端脑钠肽前体/基质金属蛋白酶-9Key words
CAD/NT-proBNP/MMP-9引用本文复制引用
蒋健刚,陈金国,刘俊..N端脑钠肽前体及基质金属蛋白酶-9与冠心病的相关性研究[J].实用医学杂志,2012,28(2):221-223,3.
