实用肝脏病杂志2012，Vol.15Issue(1)：1-3,3.DOI:10.3969/j.issn.1672-5069.2012.01.001
慢性乙型肝炎患者肝组织PDGF表达与肝窦病变的关系
Relationship between platelet-derived growth factor expression and sinusoidal lesions in patients with chronic hepatitis B
张馨 1汪茂荣 1马勇 2丁体龙 2高蕾 1李桂梅3
作者信息
- 1. 210002,南京市,解放军第81医院全军肝病中心
- 2. 安徽省蚌埠市解放军第123,医院肝病中心
- 3. 210002,南京市,解放军第81医院病理科
- 折叠
摘要
Abstract
Objective To investigate the relationship between platelet-derived growth factor (PDGF) expression and sinusoidal lesions in patients with chronic hepatitis B.Methods Immunohistochemical staining were performed for PDGF expression in hepatic tissues of 120 cases of CHB. The hepatic sinusoidal and Diss s space lesions were observed by electron microscope. Results There were constriction , emphraxis, dilation, Disse s space congestion and sinusoidal capillirization in the liver of patients with CHB;The PDGF expression was parallel to the grading and staging of hepatitis B , and to the sinusoidal and Diss s space lesions; There was a significant difference (P<0.01) among different grades; and the PDGF was strongly positively expressed in severe CHB than in the mild.Conclusion The expression of PDGF is possibly related with histology grading and staging and with sinusoidal lesions in patients with chronic hepatitis B.关键词
慢性乙型肝炎/肝活检/血小板衍生生长因子/肝窦Key words
Hepatitis B/ Liver biopsy/ Platelet-derived growth factor/ Liver sinusoid引用本文复制引用
张馨,汪茂荣,马勇,丁体龙,高蕾,李桂梅..慢性乙型肝炎患者肝组织PDGF表达与肝窦病变的关系[J].实用肝脏病杂志,2012,15(1):1-3,3.
