摘要
Abstract
Objective To explore the clinical value of low -nitrogen low-calorie parenteral nutrition ( PN ) by systematically evaluating randomized controlled trials ( RCTs ). Methods We searched databases including Cochrane Library, MEDLINE, EMBASE, Tompson SCI, CNKI, and VIP to retrieve relevant Chinese and English literatures. Data were processed and analyzed using RevMan 5. 1. 2 software. The level of evidence was assessed using GRADE3. 5. 1 software. Results Totally 11 literatures were included in the study, including two low -risk literatures, the blood glucose showed significant difference between the PN group and the control group 2, 3 , 4, 6, 7, and 8 days after surgery, among which the SMD was - 0. 73 [95% CI ( -1. 28 -0. 18 ) on the 2nd day after surgery I2 =78% , P =0. 009 ]. The incision infection rate was 3/185 in PN group and 12/179 in control group [ RR= 0.29, 95%CI(0. 10, 0.88), I22=0, P =0. 03]. The incidences of phlebitis, systemic inflammatory response, the total incidence of infection, and nutrition preparation time were statistically significant ( P < 0. 05 ) between these two groups. The PN costs and non - nutrition - related costs of these two groups were significantly different ( P < 0.05). Blood sugar, urinary tract, lung infection, total nutrition- related fees, PN equipment costs, hospital stay, hemoglobin, serum albumin, transferrin, and prealbumin showed no significant difference between the two groups one day after surgery ( P >0. 05 ). Conclusion Low - nitrogen low - calorie PN can remarkably improve high blood sugar ( especially from the second day after the surgery) reduce the incidence of postoperative infection, and decrease hospital costs; however, it has no notable effects on plasma hemoglobin, albumin, transferrin, prealbumin, and postoperative hospital stay. Since few high -quality RCTs were included in this review, whether the inclusion of more multi - center large - scale RCTs may alter the conclusion of this study requires further study.关键词
低氮/低热量/肠外营养/系统评价Key words
Low nitrogen/Low heat/Parenteral nutrition/Systematic review分类
医药卫生
