中国全科医学2012，Vol.15Issue(2)：142-144,3.
缺血后适应对急性心肌梗死合并糖尿病患者临床及预后的影响
Clinical and Prognosis Effect of Myocardial Ischemic on Acute Myocardial Infarction Patients with Diabetes Mellitus
张庆华 1闫华 1李莉 1刘晓坤 1赵碧琼 1田美荣1
作者信息
- 1. 063000,河北省唐山市工人医院心内二科
- 折叠
摘要
Abstract
Objective To evaluate the effect of ischemic on clinical course and prognosis in patients with myocardial infarction accompanied diabetes mellitus during percutaneous coronary intervention. Methods A total of 104 enrolled patients with AMI were divided into three groups: 32 patients accompanied diabetes mellitus ( group 1 ) and 35 patients without diabetes mellitus ( group 2 ) were treated with PCI operation set schemic postconditioning way and 37 control patients with AMI ( group 3 ) were treated with conventional PCI opetation. The level of plasma CK and CK - MB were detected before and after the operation. The indices of left ventricular end diastolic volume index ( LVEDVI ), left ventricular end systolic volume index ( LVESVI ) and left ventricular ejection fraction ( LVEF ) were measured by ultrasonic cardiogram three months after the onset of AMI. Malignant arrhythmia, angina occurred after AMI and death rate in hospital were compared among the three groups. Results The peak level of plasma CK and CK - MB were lower in PC group ( group 1 and group 2 ) compared with those in NPC group ( group3 ). The parameters of cardiac performance decreased significantly in PC group compared with those in NPC group. Significant difference was found in left ventricular end diastolic volume index, left ventricular end systolic volume index and left ventricular ejection fraction in PC group 3 months after PCI. The incidence of malignant arrhythmia and angina after AMI were lower in PC group compared with that in NPC group ( P <0. 05 ). After postconditioning the symptoms of all the indices of the patients in group 2 had been improved a lot than those of the patients in group 1 ( P < 0. 05 ). The difference in the death rate in hospital was not significant among the three groups ( P > 0. 05 ). Conclusion Ischemic postcondition has the effect of cardioprotection in patients with acute myocardial infarction during percutaneous coronary intervention. But the effect of cardioprotection is lower in patients with acute myocardial infarction accompanied diabetes mellitus.关键词
心肌缺血/心肌梗死/再灌注损伤/糖尿病/预后Key words
Myocardial ischemia/Myocardial infarction/Reperfusion injury/Diabetes mellitus/Prognosis分类
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张庆华,闫华,李莉,刘晓坤,赵碧琼,田美荣..缺血后适应对急性心肌梗死合并糖尿病患者临床及预后的影响[J].中国全科医学,2012,15(2):142-144,3.
