实用医学杂志2012，Vol.28Issue(1)：52-54,3.DOI:10.3969/j.issn.1006-5725.2012.01.023
蜕皮甾酮联合骨髓间充质干细胞促进烫伤皮肤愈合的实验研究
Effects of ecdysterone combined with mesenchymal stem cells on wound healing of cutis in rabbits
摘要
Abstract
Objective To investigate the effects and the mechanism of ecdysterone (EDS) combined with mesenchymal stem cells (MSCs) on wound healing of spot scald cutis in rabbits. Methods There were 18 rabbits, each has 4 scald spots on cutis that labeled randomly into Group A , B, C , and D. Group A was blank control group , Group B was treated by EDS, Group C by MSCs, and Group D by MSCs + EDS. 18 rabbits were sacrificed to obtain the histological specimen at day 5 , 10, and 15 (each 6) after modeling. The histopathological indexes were observed and the wound healing rates were calculated. Results At day 5 after modeling, the wound healing rate of Group B was obviously higher than that of Group A (P < 0.05) , the inflammatory cell infiltration of Group B and D were lower than that of Group A (P < 0.01). At day 10 after modeling, there were no significant differences in all indexes among all groups (P > 0.05). At day 15 after modeling, the wound healing rates and histopathological scores of Group B, C , and D were obviously higher than that of Group A (P < 0.05). Conclusion EDS combined with MSCs can improve the wound healing process in rabbits.关键词
间质干细胞/蜕皮甾酮/骨髓间充质干细胞/创伤愈合/烫伤/兔Key words
Ecdysterone/Mesenchymal stem cells/Wound healing/Scald/Rabbit引用本文复制引用
张子良,吴旭,张军花,张元中,冯长江,李军,吴霞,王磊..蜕皮甾酮联合骨髓间充质干细胞促进烫伤皮肤愈合的实验研究[J].实用医学杂志,2012,28(1):52-54,3.基金项目
广东省科技计划项目(编号:2008B010600006) （编号:2008B010600006）
