中国药理学通报2012，Vol.28Issue(2)：165-168,4.DOI:10.3969/j.issn.1001-1978.2012.02.005
香豆素类化合物药理和毒理作用的研究进展
Advances in pharmacology and toxicology of coumarins
摘要
Abstract
Coumarins are an important class of natural compounds found in different species of plants in nature. Experimental studies have found that coumarins have multi-biological activities such as anti-HIV, anti-tumor, anti-oxidation, anti-flammatory and other pharmacological activities, which are widely applied to anti-coagulation and lymphatic edema in clinic. In recent years, studies have found that coumarins have clear toxic effects with species and site-specific in rodents, which is related to metabolic pathways and CYP2A6 polymorphisms. In addition, toxic effects are closely related to dose and route of administration, and oral and high dose are more prone to toxicity. This paper reviews the advances in pharmacology and toxicology of coumarin and its derivatives , with a view to the development of coumarins and clinical applications.关键词
香豆素/香豆素类化合物/药理活性/遗传毒性/肺毒性/肝脏毒性Key words
coumarin/ coumarins/ pharmacological activities/genetoxic/ lung toxicity/ hepatotoxicity分类
医药卫生引用本文复制引用
孔令雷,胡金凤,陈乃宏..香豆素类化合物药理和毒理作用的研究进展[J].中国药理学通报,2012,28(2):165-168,4.基金项目
国家自然科学基金资助项目(No 90713045,30973887,30801527) （No 90713045,30973887,30801527）
国家创新药物重大专项资助项目(No 2009ZX09303-003) （No 2009ZX09303-003）
