中国药理学通报2012，Vol.28Issue(2)：282-285,4.DOI:10.3969/j.issn.1001-1978.2012.02.030
肠安康新组方抗溃疡性结肠炎大鼠的机制研究
Mechanisms of new Chang-an-kang on ulcerative colitis in rat
摘要
Abstract
Aim To observe inducible nitric oxide syn-thase ( iNOS ) activity, nitricoxide( NO ) levels, inter-leukin-8( IL-8 )levels, and c-Jun expression in colonic tissue to evaluate the possible mechanism of oral administration and colon-specific drug delivery of new Chang-an-kang. Methods Trinitrobenzene sulfonic acid( TNBS )/ethanol-induced ulcerative colitis ( UC ) rat model was prepared, and the model rats were randomly divided into eight groups: model control group, sulfasalazine tablets( SASP ) group, 1. 12,0. 56,0. 28 g · kg-1 oral administration group and 1.12,0.56, 0. 28 g · kg-1 colon-specific drug delivery group. Rats were given drugs after 24 h of modeling for 7 days successively , and on the 9 th day , iNOS activity, NO levels, IL-8 levels, and c-Jun expression were detected.There was a significant increase in iNOS activity, NO levels, IL-8 levels, and c-Jun expression between normal group and model group. Oral administration and colon-specific drug delivery of new Chang-an-kang decreased iNOS activity, NO levels, IL-8 levels, and c-Jun expression, and colon-specific drug delivery were better than oral administration. Conclusions Oral administration and colon-specific drug delivery of new Chang-an-kang may play their therapeutic role through inhibiting the inflammation due to iNOS, NO, IL-8 generation and c-Jun activation.关键词
肠安康新组方/溃疡性结肠炎/诱导型一氧化氮合酶/一氧化氮/白介素-8/c-JunKey words
new Chang-an-kang/ ulcerative colitis/ inducible nitric oxide synthase/ nitric oxide/ interleukin8/ c-Jun分类
医药卫生引用本文复制引用
于海食,陈浩,洪缨,王玉蓉,郝颖智,李阳阳..肠安康新组方抗溃疡性结肠炎大鼠的机制研究[J].中国药理学通报,2012,28(2):282-285,4.基金项目
国家科技支撑计划课题(No 2006BAI09B08) （No 2006BAI09B08）
