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丙烯海松双酰基硫脲衍生物的合成及抑菌活性研究

李健 饶小平 商士斌 高艳清

林产化学与工业2011,Vol.31Issue(5):1-5,5.
林产化学与工业2011,Vol.31Issue(5):1-5,5.

丙烯海松双酰基硫脲衍生物的合成及抑菌活性研究

Synthesis and Antibacterial Activity of Diacylthiourea Derivatives Containing Acrylpimaryl Group

李健 1饶小平 2商士斌 3高艳清4

作者信息

  • 1. 中国林业科学研究院林产化学工业研究所
  • 2. 生物质化学利用国家工程实验室
  • 3. 国家林业局林产化学工程重点开放性实验室
  • 4. 江苏省生物质能源与材料重点实验室,江苏南京210042
  • 折叠

摘要

Abstract

Acrylpimaric acid was prepared from rosin through Diels-Alder addition reaction, then series of diacylthiourea derivatives containing acrylpimaryl group were synthesized. Their structures were characterized by IR, NMR, MS, and elemental analysis. The antibacterial activity of diacylthiourea derivatives against Cram-negalive bacteria and Gram-positive bacteria were also investigated. The results indicated that diacylthiourea derivatives displayed extensive anti-bacterial activity against Gram-negative bacteria and Gram-positive bacteria. Especially, compared with commercial anti-bacterial agent (bromogeramine) , compound 4f exhibits superior anti-bacterial activity against Escherickia coli(Gram-negative bacteria).

关键词

松香/丙烯海松酸/双酰基硫脲/抑菌活性

Key words

rosin/acrylpimaric acid/diacylthiourea/antibacterial activity

分类

化学化工

引用本文复制引用

李健,饶小平,商士斌,高艳清..丙烯海松双酰基硫脲衍生物的合成及抑菌活性研究[J].林产化学与工业,2011,31(5):1-5,5.

基金项目

林业公益性行业专项(200704008) (200704008)

林产化学与工业

OA北大核心CSCDCSTPCD

0253-2417

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