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甘肃棘豆对小鼠的急性毒性研究

赵剑喜 李丽 刘晔玮 黄新异 柳军玺 邸多隆

安徽农业科学2011,Vol.39Issue(31):19180,19226,2.
安徽农业科学2011,Vol.39Issue(31):19180,19226,2.

甘肃棘豆对小鼠的急性毒性研究

Acute Toxicity of Oxytropis kansuensis Bunge on Rats

赵剑喜 1李丽 1刘晔玮 2黄新异 1柳军玺 2邸多隆2

作者信息

  • 1. 兰州大学公共卫生学院营养与食品卫生研究所,甘肃兰州73000
  • 2. 中国科学院西北特色植物资源化学重点实验室和甘肃省天然药物重点实验室,甘肃兰州730000
  • 折叠

摘要

Abstract

[Objective] The paper was to study the acute toxicity of Oxytropis kansuensis Bunge on rats. [ Method] 40 rats were randomly divided into two groups: control group (distilled water) and trial group (water extract of O. Kansuensis) to cany out the acute toxicity experiment. The trial group was supplied with the maximum does (6.0 g/ml,0. 8 ml/20 g) twice per day for continuous 7 d. [ Result] The maximal tolerance dose of rats to water extract of O. Kansuensis was more than 480 g/kg. Feeding rats with 0. Kansuensis would not lead to the death of rats within short time (7 d) and no obvious macroscopic pathological changes in the viscera of rats could be seen in naked eyes. [ Conclusion] The study provided theoretical basis for full use of 0. Kansuensis resources.

关键词

甘肃棘豆/急性毒性/最大耐受量

Key words

Oxytropis kansuensis Bunge/Acute toxicity/Maximum tolerated dose

分类

农业科技

引用本文复制引用

赵剑喜,李丽,刘晔玮,黄新异,柳军玺,邸多隆..甘肃棘豆对小鼠的急性毒性研究[J].安徽农业科学,2011,39(31):19180,19226,2.

基金项目

中国科学院重大方向性项目(KGCX2-SW-213-08) (KGCX2-SW-213-08)

国家自然科学基金项目(NSFC.NO.20775083). (NSFC.NO.20775083)

安徽农业科学

0517-6611

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